Two diphosphorylated degrons control c-Myc degradation by the Fbw7 tumor suppressor
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abl7872
Abstract: c-Myc (hereafter, Myc) is a cancer driver whose abundance is regulated by the SCFFbw7 ubiquitin ligase and proteasomal degradation. Fbw7 binds to a phosphorylated Myc degron centered at threonine 58 (T58), and mutations of Fbw7… read more here.
Keywords: myc degradation; fbw7; degradation; two diphosphorylated ... See more keywords