Isoform-dependent lysosomal degradation and internalization of apolipoprotein E requires autophagy proteins
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DOI: 10.1242/jcs.258687
Abstract: ABSTRACT The human apolipoprotein E4 isoform (APOE4) is the strongest genetic risk factor for late-onset Alzheimer's disease (AD), and lysosomal dysfunction has been implicated in AD pathogenesis. We found, by examining cells stably expressing each… read more here.
Keywords: lysosomal trafficking; apolipoprotein; degradation internalization; autophagy proteins ... See more keywords