Phthalimide conjugations for the degradation of oncogenic PI3K.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.03.066
Abstract: PI3K/Akt/mTOR pathway is crucial for carcinogenesis and its inhibitors have made a great progress in cancer treatment. However, there is still a great developing space for PI3K inhibitors as the acquired drug resistance hindered their… read more here.
Keywords: oncogenic pi3k; degradation; pi3k; conjugations degradation ... See more keywords
BI-3802 Promotes Polymerization and Degradation of Oncogenic BCL6.
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DOI: 10.1158/2159-8290.cd-rw2020-173
Abstract: The small-molecule drug BI-3802 induced the formation of BCL6 filaments leading to degradation. read more here.
Keywords: 3802 promotes; degradation oncogenic; degradation; promotes polymerization ... See more keywords