The rise and rise of protein degradation: opportunities and challenges ahead.
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DOI: 10.1016/j.drudis.2021.08.006
Abstract: The transformational mechanism of action underpinning targeted protein degradation strategies, including proteolysis-targeting chimeras (PROTACs), gives potential for potent in vivo pharmacology and has allowed projects to move rapidly to the clinic. Despite this remarkable progress,… read more here.
Keywords: degradation; rise; rise protein; degradation opportunities ... See more keywords