Fast determination of paracetamol and its hydrolytic degradation product p-aminophenol by capillary and microchip electrophoresis with contactless conductivity detection.
Sign Up to like & getrecommendations! Published in 2021 at "Electrophoresis"
DOI: 10.1002/elps.202100347
Abstract: Paracetamol (PAC) is one of the most extensively used analgesics and antipyretic drugs to treat mild and moderate pain. P-aminophenol (PAP), the main hydrolytic degradation product of PAC, can be found in environmental water. Recently,… read more here.
Keywords: microchip electrophoresis; electrophoresis; detection; hydrolytic degradation ... See more keywords
Kinetic Degradation Study of Dapagliflozin Coupled with UHPLC Separation in the Presence of Major Degradation Product and Metformin
Sign Up to like & getrecommendations! Published in 2019 at "Chromatographia"
DOI: 10.1007/s10337-019-03702-3
Abstract: A novel ultra-performance liquid chromatography with UV detector technique was established for simultaneous determination of two antidiabetic drugs, dapagliflozin (DAPA) and metformin (MET), followed by a stress degradation study. Main degradation product was chromatographically separated… read more here.
Keywords: degradation; degradation product; metformin; degradation study ... See more keywords
Sunset yellow degradation product, as an efficient water-soluble inducer, accelerates 1N4R Tau amyloid oligomerization: In vitro preliminary evidence against the food colorant safety in terms of "Triggered Amyloid Aggregation".
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.104123
Abstract: Today, Alzheimer's disease (AD) as the most prevalent type of dementia turns into one of the most severe health problems. Neurofibrillary tangle (NFT), mostly comprised of fibrils formed by Tau, is a hallmark of a… read more here.
Keywords: sunset yellow; aggregation; tau; degradation product ... See more keywords
A stability-indicating LC-MS/MS method optimization for Pemetrexed through design of experiments: Identification and characterization of major oxidative degradation product.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2020.113150
Abstract: A stability-indicating high-performance liquid chromatography method for Pemetrexed bulk was developed and validated as per the ICH guidelines by employing design of experiments methodology equipped with Box-Behnken design. The separation of Pemetrexed and its oxidative… read more here.
Keywords: degradation; degradation product; stability indicating; oxidative degradation ... See more keywords
Enrichment of Relevant Oxidative Degradation Products in Pharmaceuticals With Targeted Chemoselective Oxidation.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2018.10.059
Abstract: The ability to produce and isolate relatively pure amounts of relevant degradation products is key to several aspects of drug product development: (a) aid in the unambiguous structural identification of such degradation products, fulfilling regulatory… read more here.
Keywords: degradation; enrichment relevant; degradation product; oxidative degradation ... See more keywords
Source Attribution of the Chemical Warfare Agent Soman Using Position-Specific Isotope Analysis by 2H NMR Spectroscopy: From Precursor to Degradation Product
Sign Up to like & getrecommendations! Published in 2021 at "Analytical Chemistry"
DOI: 10.1021/acs.analchem.1c01271
Abstract: Position-specific isotope analysis (PSIA) by NMR spectroscopy is a technique that provides quantitative isotopic values for every site—a so-called isotopic fingerprint—of a compound of interest. The isotopic fingerprint can be used to link samples with… read more here.
Keywords: degradation product; analysis; isotopic; chemical ... See more keywords
Computer vision for non-contact monitoring of catalyst degradation and product formation kinetics
Sign Up to like & getrecommendations! Published in 2023 at "Chemical Science"
DOI: 10.1039/d2sc05702f
Abstract: We report a computer vision strategy for the extraction and colorimetric analysis of catalyst degradation and product-formation kinetics from video footage. The degradation of palladium(ii) pre-catalyst systems to form ‘Pd black’ is investigated as a… read more here.
Keywords: degradation product; catalyst degradation; computer vision; product ... See more keywords
Stability-Indicating UPLC and TLC-Densitometric Methods for Determination of Benztropine Mesylate and Its Carcinogenic Degradation Product.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of chromatographic science"
DOI: 10.1093/chromsci/bmx056
Abstract: Two accurate, precise and highly selective stability-indicating methods were adopted for simultaneous determination of benztropine mesylate (BNZ) in presence of its hepatotoxic and carcinogenic degradation product, benzophenone (BPH) either in pure form or in the… read more here.
Keywords: benztropine mesylate; carcinogenic degradation; degradation product; stability indicating ... See more keywords
Optimization of Solid-Phase Extraction of a Degradation Product of Novichok (A234) and its Application to Environmental Samples.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of analytical toxicology"
DOI: 10.1093/jat/bkac028
Abstract: There have been no detailed investigations regarding solid-phase-extraction (SPE) optimization and screening for the degradation products of ethyl (1-(diethylamino)ethylidene)phosphoramidofluoridate (A234) in various environmental samples. Therefore, as a first step in the selective SPE of the… read more here.
Keywords: cpd; degradation product; extraction; solid phase ... See more keywords
The fibrin/fibrinogen degradation product level on arrival in trauma patients is a better predictor of a fatal outcome than physiological or anatomical severity: A retrospective chart review
Sign Up to like & getrecommendations! Published in 2020 at "Trauma"
DOI: 10.1177/1460408620975704
Abstract: AimWe performed a retrospective investigation to determine the factors, including vital signs, severity of traumatic anatomical abnormality and biochemical data, which are most useful for predictin... read more here.
Keywords: fibrin fibrinogen; degradation product; fibrinogen degradation; trauma ... See more keywords
Degradation product of curcumin restrain Salmonella typhimurium virulent protein L-asparaginase
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Complementary and Integrative Medicine"
DOI: 10.1515/jcim-2021-0172
Abstract: Abstract Objectives Salmonella typhimurium is a pathogen responsible for causing a wide range of infectious diseases. The emergence of multi-drug resistance (MDR) in this microbe is a big challenge. L-asparaginase (less explored drug target) is… read more here.
Keywords: salmonella typhimurium; degradation; curcumin degradation; degradation product ... See more keywords