Degradation studies of Ibrutinib under stress conditions: Characterisation and structural elucidation of novel degradants.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2019.04.010
Abstract: The aim of the research work is to study the degradation behaviour of Ibrutinib (IBN) which is performed under different stress conditions according to International Conference on Harmonization guidelines (ICH). The study included monitoring degradation… read more here.
Keywords: degradation; stress conditions; drug; degradation studies ... See more keywords
Enantioselective Analysis and Degradation Studies of Four Stereoisomers of Difenoconazole in Citrus by Chiral Liquid Chromatography-Tandem Mass Spectrometry.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.0c05938
Abstract: Four difenoconazole stereoisomers were well separated on a Superchiral S-OX column. The absolute configurations of the four stereoisomers of difenoconazole eluted in an orderly fashion with the chiral column were confirmed as (2S,4S), (2S,4R), (2R,4R),… read more here.
Keywords: degradation studies; analysis degradation; four stereoisomers; enantioselective analysis ... See more keywords
Electrochemical Sensor for Detection and Degradation Studies of Ethyl Violet Dye
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c03472
Abstract: In this work, a simple and sensitive electrochemical method was developed to determine ethyl violet (EV) dye in aqueous systems by using square wave anodic stripping voltammetry (SWASV) employing a glassy carbon electrode modified with… read more here.
Keywords: violet dye; detection; ethyl violet; method ... See more keywords
Quinquennial Review of Progress in Degradation Studies and Impurity Profiling: An Instrumental Perspective Statistics
Sign Up to like & getrecommendations! Published in 2019 at "Critical Reviews in Analytical Chemistry"
DOI: 10.1080/10408347.2019.1615863
Abstract: Abstract Degradation studies of drug give insightful information about the intrinsic stability of the molecule, the possible degradents formed during shelf life and thus, aid in the subsequent development of its stable formulation. For identification… read more here.
Keywords: degradation; quinquennial review; review progress; degradation studies ... See more keywords
Mini Review on Forced Degradation Studies on Anti-Epileptic Drugs and Beyond.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chromatographic science"
DOI: 10.1093/chromsci/bmac070
Abstract: In this review on the forced degradation studies on anti-epileptic drugs and the development of validated stability-indicating assay methods for drug substances and products at a condition more severe than accelerated condition (i.e. 40 ± 2°C, 75 ± 5%… read more here.
Keywords: epileptic drugs; studies anti; forced degradation; degradation ... See more keywords
Forced degradation studies of elagolix sodium with the implementation of high resolution LC-UV-PDA-MSn (n = 1,2,3…) and NMR structural elucidation.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.2139/ssrn.4252205
Abstract: Elagolix sodium (ELS) is a marketed product using to release moderate to severe endometriosis-associated pain. It contains functional groups such as carboxyl group, secondary amino group, 2,4-dioxo pyrimidinyl and several benzyl or benzyl-like position hydrogen… read more here.
Keywords: hydrogen; elagolix sodium; group; forced degradation ... See more keywords
A SENSITIVE AND ECONOMICAL DIFFERENT SPECTROSCOPIC METHODS DEVELOPMENT AND VALIDATION FOR THE QUANTIFICATION OF CAPECITABINE AND STRESS DEGRADATION STUDIES
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Applied Pharmaceutics"
DOI: 10.22159/ijap.2023v15i3.47316
Abstract: Objective: The present investigation aims to develop an efficient, rapid, sensitive, selective, linear, and accurate method for analyzing capecitabine in bulk and tablet dosage form by UV-spectroscopy approaches. Methods: Capecitabine is an estimation by three… read more here.
Keywords: capecitabine; validation; stress degradation; method ... See more keywords
Forced Degradation Studies and Development and Validation of HPLC-UV Method for the Analysis of Velpatasvir Copovidone Solid Dispersion
Sign Up to like & getrecommendations! Published in 2022 at "Antibiotics"
DOI: 10.3390/antibiotics11070897
Abstract: Analytical methods for the drug substance and degradation products (DPs) are validated by performing forced degradation studies. Forced degradation studies of Velpatasvir (VEL) drug substance and Velpatasvir copovidone solid dispersion (VEL-CSD) were performed under the… read more here.
Keywords: velpatasvir copovidone; forced degradation; method; vel ... See more keywords
Development and Validation of Stability Indicating Method for Estimation of Buparvaquone by Forced Degradation Studies
Sign Up to like & getrecommendations! Published in 2020 at "Indian Journal of Pharmaceutical Education and Research"
DOI: 10.5530/ijper.54.3.131
Abstract: Aim: A lucid, rapid and precise stability-indicating method was developed by using HPLC for the estimation of Buparvaquone in bulk as well as pharmaceutical dosage form by forced degradation studies. Materials and Methods: Princeton C18… read more here.
Keywords: forced degradation; indicating method; stability indicating; estimation buparvaquone ... See more keywords