Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-07338-z
Abstract: Activation of the Hippo pathway effector Yap underlies many liver cancers, however no germline or somatic mutations have been identified. Autophagy maintains essential metabolic functions of the liver, and autophagy-deficient murine models develop benign adenomas… read more here.
Keywords: degradation; autophagy gatekeeper; yap autophagy; liver ... See more keywords
Silibinin inhibits the migration, invasion and epithelial-mesenchymal transition of prostate cancer by activating the autophagic degradation of YAP
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cancer"
DOI: 10.7150/jca.63514
Abstract: Silibinin (SB), a flavonoid extracted from milk thistle seeds, has been found to exert antitumor effects in numerous tumor types. Our previous study reported that SB had anti-metastatic effects in prostate cancer (PCa). However, the… read more here.
Keywords: autophagic degradation; migration invasion; invasion; degradation yap ... See more keywords