Discovery of a Brigatinib Degrader SIAIS164018 with Destroying Metastasis-Related Oncoproteins and a Reshuffling Kinome Profile.
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DOI: 10.1021/acs.jmedchem.1c00373
Abstract: Proteolysis-targeting chimera (PROTAC) is an attractive technology in drug discovery. Canonically, targets act as a basic starting point in the most previous PROTAC design. Here, we designed degraders considering from the view of clinical benefits.… read more here.
Keywords: degrader siais164018; kinome; metastasis; discovery ... See more keywords