Harnessing Chimeric Degrader Technologies for Antimicrobial Innovation.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.5c01479
Abstract: Infectious diseases remain a major global health threat, with bacterial and viral pathogens responsible for a majority of cases in both humans and animals. While small-molecule inhibitors have been the cornerstones of antimicrobial therapy, their… read more here.
Keywords: chemistry; technologies antimicrobial; harnessing chimeric; antimicrobial innovation ... See more keywords
Emerging degrader technologies engaging lysosomal pathways
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DOI: 10.1039/d2cs00624c
Abstract: Targeted protein degradation (TPD) provides unprecedented opportunities for drug discovery. While the proteolysis-targeting chimera (PROTAC) technology has already entered clinical trials and changed the landscape of small-molecule drugs, new degrader technologies harnessing alternative degradation machineries,… read more here.
Keywords: emerging degrader; degrader technologies; technologies engaging; lysosomal pathways ... See more keywords
Major Advances in Emerging Degrader Technologies
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.921958
Abstract: Recently, degrader technologies have attracted increasing interest in the academic field and the pharmaceuticals industry. As one of the degrader technologies, proteolysis-targeting chimeras (PROTACs) have emerged as an attractive pharmaceutical development approach due to their… read more here.
Keywords: major advances; degrader technologies; protacs; advances emerging ... See more keywords
Emerging Concepts of Targeted Protein Degrader Technologies via Lysosomal Pathways
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms26125582
Abstract: Targeted protein degradation (TPD) has emerged as a revolutionary strategy for modulating protein function, offering a promising alternative to traditional small-molecule inhibitors. The distinctive mechanism of action in TPD has previously allowed researchers to target… read more here.
Keywords: emerging concepts; protein degrader; concepts targeted; targeted protein ... See more keywords