Emerging degrader technologies engaging lysosomal pathways
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Society Reviews"
DOI: 10.1039/d2cs00624c
Abstract: Targeted protein degradation (TPD) provides unprecedented opportunities for drug discovery. While the proteolysis-targeting chimera (PROTAC) technology has already entered clinical trials and changed the landscape of small-molecule drugs, new degrader technologies harnessing alternative degradation machineries,… read more here.
Keywords: emerging degrader; degrader technologies; technologies engaging; lysosomal pathways ... See more keywords
Major Advances in Emerging Degrader Technologies
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.921958
Abstract: Recently, degrader technologies have attracted increasing interest in the academic field and the pharmaceuticals industry. As one of the degrader technologies, proteolysis-targeting chimeras (PROTACs) have emerged as an attractive pharmaceutical development approach due to their… read more here.
Keywords: major advances; degrader technologies; protacs; advances emerging ... See more keywords