Discovery of AXL Degraders with Improved Potencies in Triple-Negative Breast Cancer (TNBC) Cells.
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DOI: 10.1021/acs.jmedchem.2c01682
Abstract: AXL kinase is heavily involved in tumorigenesis, metastasis, and drug resistance of many cancers, and several AXL inhibitors are in clinical investigations. Recent studies demonstrated that the N-terminal distal region of AXL plays more important… read more here.
Keywords: discovery axl; axl degraders; improved potencies; degraders improved ... See more keywords