Identification and expression of bifunctional acid urea degrading enzyme/urethanase from Enterobacter sp. R-SYB082 and its application in degradation of ethyl carbamate in Chinese rice wine (Huangjiu).
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.11818
Abstract: BACKGROUND Ethyl carbamate (EC) is a potential carcinogen existing in fermented foods such as Chinese rice wine (Huangjiu). Since urea is an important precursor of EC, the degradation of urea could be an effective way… read more here.
Keywords: urea degrading; acid urea; chinese rice; rice wine ... See more keywords
Memantine, a Noncompetitive N-Methyl-d-Aspartate Receptor Antagonist, Attenuates Cerebral Amyloid Angiopathy by Increasing Insulin-Degrading Enzyme Expression
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Neurobiology"
DOI: 10.1007/s12035-019-01678-7
Abstract: Sporadic cerebral amyloid angiopathy (CAA) is characterized by cerebrovascular amyloid beta (Aβ) deposits and causes cerebral hemorrhages and dementia in elderly people. Memantine is used in Alzheimer’s disease to inhibit the glutamatergic system by blocking… read more here.
Keywords: amyloid angiopathy; cerebral amyloid; methyl aspartate; degrading enzyme ... See more keywords
Identification of indole-based activators of insulin degrading enzyme.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113982
Abstract: Insulin degrading enzyme (IDE) is a zinc metalloprotease that cleaves numerous substrates among which amyloid-β and insulin. It has been linked through genetic studies to the risk of type-2 diabetes (T2D) or Alzheimer's disease (AD).… read more here.
Keywords: identification indole; degrading enzyme; insulin degrading; activators insulin ... See more keywords
Expression, functional analysis and mutation of a novel neutral zearalenone-degrading enzyme.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.06.111
Abstract: The crops and grains were often contaminated by high level of mycotoxin zearalenone (ZEN). In order to remove ZEN and keep food safe, ZEN-degrading or detoxifying enzymes are urgently needed. Here, a newly identified lactonohydrolase… read more here.
Keywords: degrading enzyme; analysis; zen degrading; zhd518 ... See more keywords
Molecular Determinants of Substrate Specificity in Human Insulin-Degrading Enzyme.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemistry"
DOI: 10.1021/acs.biochem.8b00474
Abstract: Insulin-degrading enzyme (IDE) is a 110 kDa chambered zinc metalloendopeptidase that degrades insulin, amyloid β, and other intermediate-sized aggregation prone peptides that adopt β-structures. Structural studies of IDE in complex with multiple physiological substrates have… read more here.
Keywords: insulin; degrading enzyme; insulin degrading; active site ... See more keywords
Stabilized β-Hairpin Peptide Inhibits Insulin Degrading Enzyme.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b00418
Abstract: Insulin-degrading enzyme (IDE) plays a critical role in both the proteolytic degradation and inactivation of insulin. The exploration of novel IDE inhibitors could aid in the study of novel therapeutics for type-2 diabetes. Herein, we… read more here.
Keywords: peptide; degrading enzyme; insulin degrading; hairpin peptide ... See more keywords
A guanidine-degrading enzyme controls genomic stability of ethylene-producing cyanobacteria
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DOI: 10.1038/s41467-021-25369-x
Abstract: Recent studies have revealed the prevalence and biological significance of guanidine metabolism in nature. However, the metabolic pathways used by microbes to degrade guanidine or mitigate its toxicity have not been widely studied. Here, via… read more here.
Keywords: ethylene; degrading enzyme; genomic stability; guanidine degrading ... See more keywords
Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme
Sign Up to like & getrecommendations! Published in 2019 at "Nature chemical biology"
DOI: 10.1038/s41589-019-0271-0
Abstract: Enzymes that act on multiple substrates are common in biology but pose unique challenges as therapeutic targets. The metalloprotease insulin-degrading enzyme (IDE) modulates blood glucose levels by cleaving insulin, a hormone that promotes glucose clearance.… read more here.
Keywords: insulin; glucagon; degrading enzyme; insulin degrading ... See more keywords
Innovative microscale workflow from fungi cultures to Cell Wall‐Degrading Enzyme screening
Sign Up to like & getrecommendations! Published in 2019 at "Microbial Biotechnology"
DOI: 10.1111/1751-7915.13405
Abstract: This study aimed at developing a complete miniaturized high‐throughput screening workflow for the evaluation of the Cell Wall‐Degrading Enzyme (CWDE) activities produced by any fungal strain directly cultivated on raw feedstock in a submerged manner.… read more here.
Keywords: cwde activities; wall degrading; degrading enzyme; microscale workflow ... See more keywords
Optimization of a nicotine degrading enzyme for potential use in treatment of nicotine addiction
Sign Up to like & getrecommendations! Published in 2019 at "BMC Biotechnology"
DOI: 10.1186/s12896-019-0551-5
Abstract: BackgroundSmoking and tobacco use continue to be the largest preventable causes of death globally. A novel therapeutic approach has recently been proposed: administration of an enzyme that degrades nicotine, the main addictive component of tobacco,… read more here.
Keywords: nicotine addiction; nicotine; use; degrading enzyme ... See more keywords
The core sequence of PIF competes for insulin/amyloid β in insulin degrading enzyme: potential treatment for Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.26057
Abstract: The central pathological feature of Alzheimer's disease (AD) is the sequential proteolytic processing of amyloid precursor protein (APP) to amyloid-β peptides (Aβ) agglomeration. The clearance of Aβ may be induced by the large zinc-binding protease… read more here.
Keywords: insulin; degrading enzyme; insulin degrading; alzheimer disease ... See more keywords