Autonomic nervous system receptor-mediated regulation of mast cell degranulation modulates the inflammation after corneal epithelial abrasion.
Sign Up to like & getrecommendations! Published in 2022 at "Experimental eye research"
DOI: 10.1016/j.exer.2022.109065
Abstract: Mast cells (MCs) regulate wound healing and are influenced by the autonomic nervous system (ANS). However, the underlying mechanisms affecting wound healing outcomes remain elusive. Here, we explored the specific role of the ANS by… read more here.
Keywords: mast; abrasion; nervous system; autonomic nervous ... See more keywords
Endogenous sulfur dioxide is a novel inhibitor of hypoxia-induced mast cell degranulation
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Advanced Research"
DOI: 10.1016/j.jare.2020.08.017
Abstract: Graphical abstract Endogenous sulfur dioxide is a novel inhibitor of hypoxia-induced mast cell degranulation. Endogenous SO2/AAT pathway exists in MCs. Mast cell-derived SO2 upregulates cAMP level through activation of AC and inhibition of PDE, thereby… read more here.
Keywords: degranulation; sulfur dioxide; mast; mast cell ... See more keywords
Trigonelline: An alkaloid with anti-degranulation properties.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular immunology"
DOI: 10.1016/j.molimm.2019.12.020
Abstract: Trigonelline, one of the alkaloids contained in coffee, is important not only as one of the constituents of aroma and flavor in coffee but also as a useful source of nutrition. Its anti-microbial, anti-carcinogenic, and… read more here.
Keywords: degranulation; trigonelline; anti degranulation; degranulation effect ... See more keywords
Eriodictyol-Amplified 67-kDa Laminin Receptor Signaling Potentiates the Antiallergic Effect of O-Methylated Catechin.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.1c00337
Abstract: (-)-Epigallocatechin-3-O-(3-O-methyl) gallate (1, EGCG3″Me), an antiallergic O-methylated catechin, is present in high quantities in the green tea cultivar "Benifuuki" (Camellia sinensis L.). Previous studies have shown that EGCG3″Me inhibited basophil degranulation mediated through the cell-surface… read more here.
Keywords: degranulation; effect; egcg3; laminin receptor ... See more keywords
SARS-CoV-2-triggered mast cell rapid degranulation induces alveolar epithelial inflammation and lung injury
Sign Up to like & getrecommendations! Published in 2021 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-021-00849-0
Abstract: SARS-CoV-2 infection-induced hyper-inflammation links to the acute lung injury and COVID-19 severity. Identifying the primary mediators that initiate the uncontrolled hypercytokinemia is essential for treatments. Mast cells (MCs) are strategically located at the mucosa and… read more here.
Keywords: sars cov; degranulation; alveolar epithelial; inflammation ... See more keywords
Rapid identification of human mast cell degranulation regulators using functional genomics coupled to high-resolution confocal microscopy
Sign Up to like & getrecommendations! Published in 2020 at "Nature protocols"
DOI: 10.1038/s41596-019-0288-6
Abstract: Targeted functional genomics represents a powerful approach for studying gene function in vivo and in vitro. However, its application to gene expression studies in human mast cells has been hampered by low yields of human… read more here.
Keywords: degranulation; microscopy; mast; human mast ... See more keywords
Phospholipid transfer protein and alpha-1 antitrypsin regulate Hck kinase activity during neutrophil degranulation
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-33851-8
Abstract: Excessive neutrophil degranulation is a common feature of many inflammatory disorders, including alpha-1 antitrypsin (AAT) deficiency. Our group has demonstrated that phospholipid transfer protein (PLTP) prevents neutrophil degranulation but serine proteases, which AAT inhibits, cleave… read more here.
Keywords: degranulation; pltp; kinase; aat ... See more keywords
Docosahexaenoyl ethanolamide mitigates IgE-mediated allergic reactions by inhibiting mast cell degranulation and regulating allergy-related immune cells
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-52317-z
Abstract: Docosahexaenoic acid (DHA) is a long-chain polyunsaturated fatty acid mainly found in fish oil. Although several studies have suggested that it can alleviate allergy symptoms, its mechanism of action remains to be elucidated. In the… read more here.
Keywords: ige mediated; degranulation; cell degranulation; docosahexaenoyl ethanolamide ... See more keywords
Surface-enhanced Raman spectroscopy analysis of mast cell degranulation induced by low-intensity laser.
Sign Up to like & getrecommendations! Published in 2019 at "IET nanobiotechnology"
DOI: 10.1049/iet-nbt.2019.0145
Abstract: Mast cell (MC) degranulation is an important step in the healing process. In this study, silver-nanoparticles-based surface-enhanced Raman spectroscopy (SERS) was used to investigate the spectral characteristics of degranulation of MCs activated by low-intensity laser.… read more here.
Keywords: degranulation; cell degranulation; analysis; intensity ... See more keywords
Tirofiban potentiates agonist-induced platelet activation and degranulation, despite effectively inhibiting aggregation
Sign Up to like & getrecommendations! Published in 2022 at "Platelets"
DOI: 10.1080/09537104.2022.2078489
Abstract: Abstract We aimed to investigate the effects of integrin αIIbβ3 inhibitor tirofiban on hallmarks of platelet activation, degranulation, and aggregation during its use to analyze activated but non-complexed platelets via flow cytometry. To do so,… read more here.
Keywords: platelet activation; aggregation; tirofiban; degranulation ... See more keywords
Spirodela polyrhiza extract modulates the activation of atopic dermatitis-related ion channels, Orai1 and TRPV3, and inhibits mast cell degranulation
Sign Up to like & getrecommendations! Published in 2017 at "Pharmaceutical Biology"
DOI: 10.1080/13880209.2017.1300819
Abstract: Abstract Context: Spirodela polyrhiza (L.) Schleid. (Lemnaceae), Spirodelae Herba (SH), has been known to relieve inflammation, urticaria and skin symptoms including pruritus, eczema and rash. Objective: The effects of SH extract on two calcium ion… read more here.
Keywords: degranulation; orai1 trpv3; ion channels; ion ... See more keywords