Evolution of Substrates and Components of the Pro/N-Degron Pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemistry"
DOI: 10.1021/acs.biochem.9b00953
Abstract: Gid4, a subunit of the ubiquitin ligase GID, is the recognition component of the Pro/N-degron pathway. Gid4 targets proteins in particular through their N-terminal (Nt) proline (Pro) residue. In Saccharomyces cerevisiae and other Saccharomyces yeasts,… read more here.
Keywords: degron pathway; lactis fbp1; evolution; pro degron ... See more keywords
The Cys-N-degron pathway modulates pexophagy through the N-terminal oxidation and arginylation of ACAD10.
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2126617
Abstract: In the N-degron pathway, N-recognins recognize cognate substrates for degradation via the ubiquitin (Ub)-proteasome system (UPS) or the autophagy-lysosome system (hereafter autophagy). We have recently shown that the autophagy receptor SQSTM1/p62 (sequestosome 1) is an… read more here.
Keywords: cys degron; degron; sqstm1 p62; degron pathway ... See more keywords
Molecular determinants of protein half-life in chloroplasts with focus on the Clp protease system
Sign Up to like & getrecommendations! Published in 2023 at "Biological Chemistry"
DOI: 10.1515/hsz-2022-0320
Abstract: Abstract Proteolysis is an essential process to maintain cellular homeostasis. One pathway that mediates selective protein degradation and which is in principle conserved throughout the kingdoms of life is the N-degron pathway, formerly called the… read more here.
Keywords: system; determinants protein; degron pathway; protease system ... See more keywords
A Yeast-Based Functional Assay to Study Plant N-Degron – N-Recognin Interactions
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2021.806129
Abstract: The N-degron pathway is a branch of the ubiquitin-proteasome system where amino-terminal residues serve as degradation signals. In a synthetic biology approach, we expressed ubiquitin ligase PRT6 and ubiquitin conjugating enzyme 2 (AtUBC2) from Arabidopsis… read more here.
Keywords: degron; yeast based; degron pathway; plant degron ... See more keywords