Functional analysis of the dehydratase domains of a PUFA synthase from Thraustochytrium in Escherichia coli
Sign Up to like & getrecommendations! Published in 2017 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-017-8635-4
Abstract: Thraustochytrium sp. 26185, a unicellular marine protist, synthesizes docosahexaenoic acid, an omega-3 very long chain polyunsaturated fatty acid (VLC-PUFAs), by a polyunsaturated fatty acid (PUFA) synthase comprising three large subunits with multiple catalytic dehydratase (DH)… read more here.
Keywords: synthase; pufa synthase; analysis; thraustochytrium ... See more keywords
In vitro characterization of N-terminal truncated EpsC from Bacillus subtilis 168, a UDP-N-acetylglucosamine 4,6-dehydratase.
Sign Up to like & getrecommendations! Published in 2018 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2018.09.005
Abstract: Bacillus subtilis 168 EpsC is annotated as "Probable polysaccharide biosynthesis protein" in the SwissProt database. epsC is part of the eps operon, thought to be involved in the biosynthesis of exopolymeric substances (EPS). The present… read more here.
Keywords: vitro characterization; dehydratase; subtilis 168; spectroscopy ... See more keywords
Rational engineering of diol dehydratase enables 1,4-butanediol biosynthesis from xylose.
Sign Up to like & getrecommendations! Published in 2017 at "Metabolic engineering"
DOI: 10.1016/j.ymben.2017.02.003
Abstract: Establishing novel synthetic routes for microbial production of chemicals often requires overcoming pathway bottlenecks by tailoring enzymes to enhance bio-catalysis or even achieve non-native catalysis. Diol dehydratases have been extensively studied for their interactions with… read more here.
Keywords: engineering; biosynthesis; dehydratase; diol dehydratase ... See more keywords
Biochemical and structural characterization of L-2-keto-3-deoxyarabinonate dehydratase: A unique catalytic mechanism in the Class I aldolase protein superfamily.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemistry"
DOI: 10.1021/acs.biochem.0c00515
Abstract: L-2-Keto-3-deoxyarabinonate (L-KDA) dehydratase (AraD) catalyzes the hydration of L-KDA to α-ketoglutaric semialdehyde in the non-phosphorylative L-arabinose pathway from bacteria, and belongs to the dihydrodipicolinate synthase (DHDPS)/N-acetylneuraminate lyase (NAL) protein superfamily. All members of this superfamily,… read more here.
Keywords: catalytic mechanism; keto deoxyarabinonate; dehydratase; keto ... See more keywords
Identification of Scytalone Dehydratase Inhibitors Effective against Melanin Biosynthesis Dehydratase Inhibitor-Resistant Pyricularia oryzae.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.1c04984
Abstract: Melanin is a secondary metabolite required for the infection of the rice blast fungus Pyricularia oryzae. Melanin biosynthesis enzymes are targets for controlling rice blast disease, and three types of commercial melanin biosynthesis inhibitors (MBIs)… read more here.
Keywords: dehydratase; melanin biosynthesis; mbi; rice ... See more keywords
Structural insights into bifunctional thaumarchaeal crotonyl-CoA hydratase and 3-hydroxypropionyl-CoA dehydratase from Nitrosopumilus maritimus
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-02180-8
Abstract: The ammonia-oxidizing thaumarchaeal 3-hydroxypropionate/4-hydroxybutyrate (3HP/4HB) cycle is one of the most energy-efficient CO2 fixation cycles discovered thus far. The protein encoded by Nmar_1308 (from Nitrosopumilus maritimus SCM1) is a promiscuous enzyme that catalyzes two essential… read more here.
Keywords: crotonyl coa; dehydratase; coa; coa hydratase ... See more keywords
Evidence that the metabolite repair enzyme NAD(P)HX epimerase has a moonlighting function
Sign Up to like & getrecommendations! Published in 2018 at "Bioscience Reports"
DOI: 10.1042/bsr20180223
Abstract: NAD(P)H-hydrate epimerase (EC 5.1.99.6) is known to help repair NAD(P)H hydrates (NAD(P)HX), which are damage products existing as R and S epimers. The S epimer is reconverted to NAD(P)H by a dehydratase; the epimerase facilitates… read more here.
Keywords: epimerase; evidence; dehydratase; function ... See more keywords
Commentary on "Urinary L-erythro-β-hydroxyasparagine - a novel serine racemase inhibitor and substrate of the Zn2+-dependent D-serine dehydratase".
Sign Up to like & getrecommendations! Published in 2021 at "Bioscience reports"
DOI: 10.1042/bsr20211524
Abstract: The analysis of the urine contents can be informative of physiological homeostasis, and it has been speculated that the levels of urinary D-serine (D-ser) could inform about neurological and renal disorders. By analysing the levels… read more here.
Keywords: commentary urinary; dehydratase; ser; racemase ... See more keywords
NAD(P)HX dehydratase (NAXD) deficiency: a novel neurodegenerative disorder exacerbated by febrile illnesses
Sign Up to like & getrecommendations! Published in 2019 at "Brain"
DOI: 10.1093/brain/awy310
Abstract: Physical stress, including high temperatures, may damage the central metabolic nicotinamide nucleotide cofactors [NAD(P)H], generating toxic derivatives [NAD(P)HX]. The highly conserved enzyme NAD(P)HX dehydratase (NAXD) is essential for intracellular repair of NAD(P)HX. Here we present… read more here.
Keywords: disorder; dehydratase naxd; nad dehydratase; dehydratase ... See more keywords
d-Ribose Catabolism in Archaea: Discovery of a Novel Oxidative Pathway in Haloarcula Species
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Bacteriology"
DOI: 10.1128/jb.00608-19
Abstract: The utilization and degradation of d-ribose in archaea, the third domain of life, have not been analyzed so far. We show that Haloarcula species utilize d-ribose, which is degraded to α-ketoglutarate via a novel oxidative… read more here.
Keywords: dehydratase; oxidative degradation; oxidative pathway; degradation ... See more keywords