Dehydration of Amides to Nitriles under Conditions of a Catalytic Appel Reaction.
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DOI: 10.1021/acs.orglett.7b03862
Abstract: A highly expedient protocol for a catalytic Appel-type dehydration of amides to nitriles has been developed that employs oxalyl chloride and triethylamine along with triphenylphosphine oxide as a catalyst. The reactions are usually complete in… read more here.
Keywords: nitriles conditions; catalytic appel; conditions catalytic; dehydration amides ... See more keywords