Dehydrative Condensation of Carboxylic Acids with Amines Promoted by HBF4/MS 5A
Sign Up to like & getrecommendations! Published in 2024 at "Asian Journal of Organic Chemistry"
DOI: 10.1002/ajoc.202300660
Abstract: The direct dehydrative condensation of carboxylic acids with amines is one of the most straightforward methods for the synthesis of amides. We discovered that HBF4 effectively promotes the coupling of several N‐protected amino acids in… read more here.
Keywords: acids amines; condensation carboxylic; carboxylic acids; hbf4 dehydrative ... See more keywords
Diboronic Acid Anhydride-Catalyzed Direct Peptide Bond Formation Enabled by Hydroxy-Directed Dehydrative Condensation.
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DOI: 10.1021/acs.orglett.0c03252
Abstract: We report the catalytic direct peptide bond formations via dehydrative condensation of β-hydroxy-α-amino acids, affording the serine, threonine, or β-hydroxyvaline-derived peptides in high to excellent yields with high functional group tolerance, minimum epimerization, and excellent… read more here.
Keywords: hydroxy directed; diboronic acid; acid anhydride; dehydrative condensation ... See more keywords