C3 versus C5 Regioselectivity in the Intramolecular Dehydrative Friedel-Crafts Alkylation of Indole C4-Tethered Carbinols.
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DOI: 10.1021/acs.orglett.5c00420
Abstract: Described herein is a mild catalytic dehydrative Friedel-Crafts alkylation of 1,1-diarylalkanols─a challenging reaction with exceedingly rare previous success, presumably because of the unfavorable steric hindrance around the reactive centers and the competitive E1 reaction. Executing… read more here.
Keywords: crafts alkylation; friedel crafts; dehydrative friedel; versus regioselectivity ... See more keywords