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   Articles with "dehydroalanine" as a keyword



Sulfa-Michael Addition on Dehydroalanine: A Versatile Reaction for Protein Modifications.

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recommendations! Published in 2024 at "Organic letters"

DOI: 10.1021/acs.orglett.4c02970

Abstract: Chemical modification of proteins has been widely applied in diagnostic and therapeutic processes. Here, we report a novel bioconjugation between sulfinic acids and amino acid dehydroalanine (Dha) in the context of both small molecules and… read more here.

Keywords: sulfa michael; michael addition; versatile reaction; addition dehydroalanine ... See more keywords

Poly(dehydroalanine): Synthesis, Properties, and Functional Diversification of a Fluorescent Polypeptide.

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recommendations! Published in 2022 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.2c00383

Abstract: Via the design of a new, soluble poly(S-alkyl-l-cysteine) precursor, a route was developed for the successful preparation of long-chain poly(dehydroalanine), ADH, as well as the incorporation of dehydroalanine residues and ADH segments into copolypeptides. Based… read more here.

Keywords: dehydroalanine; fluorescent polypeptide; poly dehydroalanine;

Development in Maillard Reaction and Dehydroalanine Pathway Markers during Storage of UHT Milk Representing Differences in Casein Micelle Size and Sedimentation

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recommendations! Published in 2022 at "Foods"

DOI: 10.3390/foods11101525

Abstract: Ultra-high temperature (UHT) processing of milk can result in protein changes during storage; however, the progress of dehydroalanine (DHA) mediated protein cross-linking and Maillard reactions in relation to the sediment formation have not been investigated… read more here.

Keywords: reaction; maillard reaction; dehydroalanine; sedimentation ... See more keywords

Site-Specific Conversion of Cysteine in a Protein to Dehydroalanine Using 2-Nitro-5-thiocyanatobenzoic Acid

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recommendations! Published in 2021 at "Molecules"

DOI: 10.3390/molecules26092619

Abstract: Dehydroalanine exists natively in certain proteins and can also be chemically made from the protein cysteine. As a strong Michael acceptor, dehydroalanine in proteins has been explored to undergo reactions with different thiolate reagents for… read more here.

Keywords: protein; thiocyanatobenzoic acid; dehydroalanine; ubiquitin ubiquitin ... See more keywords

Giese-type alkylation of dehydroalanine derivatives via silane-mediated alkyl bromide activation

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recommendations! Published in 2024 at "Beilstein Journal of Organic Chemistry"

DOI: 10.3762/bjoc.20.271

Abstract: The rising popularity of bioconjugate therapeutics has led to growing interest in late-stage functionalization (LSF) of peptide scaffolds. α,β-Unsaturated amino acids like dehydroalanine (Dha) derivatives have emerged as particularly useful structures, as the electron-deficient olefin… read more here.

Keywords: chemistry; giese type; silane mediated; alkylation ... See more keywords