Discovery of Dehydroamino Acid Residues in the Capsid and Matrix Structural Proteins of HIV-1.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.1c00867
Abstract: Human immunodeficiency virus type 1 (HIV-1) remains a deadly infectious disease despite existing antiretroviral therapies. A comprehensive understanding of the specific mechanisms of viral infectivity remains elusive and currently limits the development of new and… read more here.
Keywords: discovery dehydroamino; acid residues; dehydroamino acids; dehydroamino acid ... See more keywords
Synthesis and Studies of Bulky Cycloalkyl α,β-Dehydroamino Acids that Enhance Proteolytic Stability.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01962
Abstract: Three new bulky cycloalkyl α,β-dehydroamino acids (ΔAAs) have been designed and synthesized. Each residue enhances the rigidity of model peptides and their stability to proteolysis, with larger ring sizes exhibiting greater effects. Peptides containing bulky… read more here.
Keywords: cycloalkyl; bulky cycloalkyl; dehydroamino acids; proteolytic stability ... See more keywords
Structure and Function of a Dehydrating Condensation Domain in Nonribosomal Peptide Biosynthesis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c13404
Abstract: Dehydroamino acids are important structural motifs and biosynthetic intermediates for natural products. Many bioactive natural products of nonribosomal origin contain dehydroamino acids; however, the biosynthesis of dehydroamino acids in most nonribosomal peptides is not well… read more here.
Keywords: function; biosynthesis; cmodaa; dehydroamino acids ... See more keywords
Molecular flavin catalysts for C–H functionalisation and derivatisation of dehydroamino acids
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d2sc04341f
Abstract: In nature, the isoalloxazine heterocycle of flavin cofactors undergoes reversible covalent bond formation with a variety of different reaction partners. These intermediates play a crucial role inter alia as the signalling states and in selective… read more here.
Keywords: molecular flavin; dehydroamino acids; dehydroamino; derivatisation ... See more keywords