Engineered yeast for efficient de novo synthesis of 7‐dehydrocholesterol
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28055
Abstract: The synthesis of vitamin D3 precursor 7‐dehydrocholesterol (7‐DHC) by microbial fermentation has much attracted attention owing to its advantages of environmental protection. In this study, Saccharomyces cerevisiae was engineered for a de novo biosynthesis of… read more here.
Keywords: gene; dehydrocholesterol; dhc titer; synthesis ... See more keywords
Ergosterol increases 7-dehydrocholesterol, a cholesterol precursor, and decreases cholesterol in human HepG2 cells.
Sign Up to like & getrecommendations! Published in 2022 at "Lipids"
DOI: 10.1002/lipd.12357
Abstract: Current treatment approaches for hyperlipidemia rely mainly on reducing the cholesterol level by inhibiting 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), which is involved in the presqualene pathway of cholesterol biosynthesis. Finding a compound that instead targets the postsqualene… read more here.
Keywords: human hepg2; dehydrocholesterol; dhcr7; cholesterol ... See more keywords
Voltammetry of 7-dehydrocholesterol as a new and useful tool for Smith-Lemli-Opitz syndrome diagnosis.
Sign Up to like & getrecommendations! Published in 2021 at "Talanta"
DOI: 10.1016/j.talanta.2021.122260
Abstract: 7-Dehydrocholesterol is an essential biomarker of Smith-Lemli-Opitz syndrome, a congenital autosomal recessive disorder. This study shows for the first time that electrochemical oxidation of 7-dehydrocholesterol can be used for its voltammetric determination. Two classes of… read more here.
Keywords: lemli opitz; dehydrocholesterol; smith lemli; opitz syndrome ... See more keywords
Pathway Refactoring for Efficient 7-Dehydrocholesterol Production in Saccharomyces cerevisiae.
Sign Up to like & getrecommendations! Published in 2025 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.5c00032
Abstract: 7-Dehydrocholesterol (7-DHC) is a subcutaneous sterol and a precursor to various active vitamin D3. Here, a Saccharomyces cerevisiae strain equipped with the de novo biosynthetic pathway for 7-DHC was constructed. 109.0 mg L-1 of 7-DHC… read more here.
Keywords: pathway refactoring; saccharomyces cerevisiae; dhc; dehydrocholesterol ... See more keywords
Radiation-induced ferroptosis via liposomal delivery of 7-Dehydrocholesterol
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Nanobiotechnology"
DOI: 10.1186/s12951-025-03303-3
Abstract: Ferroptosis is an emerging cell death mechanism characterized by uncontrolled lipid peroxidation. However, selectively inducing ferroptosis in cancer cells remains a challenge. We explore an approach that enables ferroptosis induction through external radiation. The key… read more here.
Keywords: radiation; radiation induced; delivery; ferroptosis ... See more keywords
Reengineering of 7-dehydrocholesterol biosynthesis in Saccharomyces cerevisiae using combined pathway and organelle strategies
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.978074
Abstract: 7-Dehydrocholesterol (7-DHC) is a widely used sterol and a precursor of several costly steroidal drugs. In this study, 7-DHC biosynthesis pathway was constructed and modified in Saccharomyces cerevisiae. Firstly, the biosynthesis pathway was constructed by… read more here.
Keywords: biosynthesis; dehydrocholesterol; dhc; saccharomyces cerevisiae ... See more keywords