New chemotype of selective and potent inhibitors of human delta 24-dehydrocholesterol reductase.
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DOI: 10.1016/j.ejmech.2017.08.011
Abstract: The enzyme Δ24-dehydrocholesterol reductase (DHCR24) catalyzes the reduction of the Δ24-double bond in the side chain of cholesterol precursors. Recent biochemical investigations fuel the hope that inhibition of DHCR24, resulting in an accumulation of desmosterol,… read more here.
Keywords: new chemotype; selective potent; dehydrocholesterol reductase; dhcr24 ... See more keywords