An effective synthesis of ursodeoxycholic acid from dehydroepiandrosterone
Sign Up to like & getrecommendations! Published in 2021 at "Steroids"
DOI: 10.1016/j.steroids.2021.108870
Abstract: A novel synthetic route of producing ursodeoxycholic acid (UDCA) was developed through multiple reactions from plant-source dehydroepiandrosterone (DHEA), with a Mistunobu reaction and regioselective allyl oxidationat as the key steps. The reaction conditions of the… read more here.
Keywords: effective synthesis; ursodeoxycholic acid; synthesis ursodeoxycholic; dehydroepiandrosterone ... See more keywords
Determination of dehydroepiandrosterone and its biologically active oxygenated metabolites in human plasma evinces a hormonal imbalance during HIV-TB coinfection
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-24771-8
Abstract: An estimated one third of the world’s population is affected by latent tuberculosis (TB), which once active represents a leading cause of death among infectious diseases. Human immunodeficiency virus (HIV) infection is a main predisposing… read more here.
Keywords: hormonal imbalance; hiv; dehydroepiandrosterone; oxygenated metabolites ... See more keywords
Synthesis, molecular docking, molecular dynamics and evaluation of Drug-Likeness properties of the fused N-Formyl pyrazoline substituted new dehydroepiandrosterone derivatives
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2022.2034667
Abstract: Abstract The hybrid molecules bearing heterocyclic structures in the A or D rings of steroids have significant biological activity. 16 (E)-Hetereoarylidene steroids were synthesized from the reaction of different heteroaromatic carbaldehydes and trans-Dehydroepiandrosterone (DHEA) in… read more here.
Keywords: molecular docking; pyrazoline substituted; dehydroepiandrosterone; formyl pyrazoline ... See more keywords
Apigenin exerts protective effect and restores ovarian function in dehydroepiandrosterone induced polycystic ovary syndrome rats: a biochemical and histological analysis
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Medicine"
DOI: 10.1080/07853890.2022.2034933
Abstract: Abstract Background Polycystic ovarian syndrome (PCOS) is one of the major causes encouraging the elevation of androgens, obesity along with menstrual complications. Here we study the effect of Apigenin in rat model of polycystic ovarian… read more here.
Keywords: effect; apigenin; dehydroepiandrosterone; syndrome ... See more keywords
Correlation of dehydroepiandrosterone with diabetic nephropathy and its clinical value in early detection
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Diabetes Investigation"
DOI: 10.1111/jdi.13862
Abstract: This study was carried out to assess the association of dehydroepiandrosterone (DHEA) with diabetic nephropathy (DN) in patients with type 2 diabetes mellitus to better predict the progression of diabetic nephropathy. read more here.
Keywords: nephropathy clinical; correlation dehydroepiandrosterone; clinical value; dehydroepiandrosterone ... See more keywords
Intravaginal dehydroepiandrosterone for genitourinary symptoms of the menopause: Is the evidence sufficient?
Sign Up to like & getrecommendations! Published in 2022 at "Post Reproductive Health"
DOI: 10.1177/20533691221135906
Abstract: Intravaginal dehydroepiandrosterone (DHEA) is a locally metabolised estrogen and androgen precursor, licensed in 2018 in the EU for moderate to severe vulvovaginal atrophy in postmenopausal women. A literature search revealed four original trials suitable for… read more here.
Keywords: dyspareunia; dehydroepiandrosterone genitourinary; dehydroepiandrosterone; genitourinary symptoms ... See more keywords
Dehydroepiandrosterone, Cancer, and Aging
Sign Up to like & getrecommendations! Published in 2022 at "Aging and Disease"
DOI: 10.14336/ad.2021.0913
Abstract: The biological significance of dehydroepiandrosterone (DHEA) which, in the form of its sulfated ester is the most abundant steroid hormone in human plasma, is an enigma. Over the past years, numerous investigators have reported preclinical… read more here.
Keywords: cancer aging; clinical trials; dehydroepiandrosterone; dhea ... See more keywords
The neuroendocrine effects of dehydroepiandrosterone and 17β-estradiol in the in vitro preterm hyperoxia infant model.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of integrative neuroscience"
DOI: 10.31083/j.jin.2021.01.333
Abstract: Preterm birth causes neurological deficits. Previously, we demonstrated that fetal zone steroids reduce hyperoxia-mediated cell death in vitro. In immature oligodendrocytes (OLN-93 cells), dehydroepiandrosterone + 17β-estradiol co-treatment had synergistic beneficial effects while signals were transduced… read more here.
Keywords: estradiol dehydroepiandrosterone; oln cells; hyperoxia; treatment ... See more keywords
Low Serum Dehydroepiandrosterone and Dehydroepiandrosterone Sulfate Are Associated With Coronary Heart Disease in Men With Type 2 Diabetes Mellitus
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.890029
Abstract: Aims Sex hormones play an important role in the pathogenesis of cardiovascular disease (CVD). This cross-sectional study aimed to explore the associations of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) with coronary heart disease (CHD) and… read more here.
Keywords: serum; disease; dehydroepiandrosterone; dehydroepiandrosterone sulfate ... See more keywords
Advances in understanding the effect and mechanism of dehydroepiandrosterone on diminished ovarian reserve.
Sign Up to like & getrecommendations! Published in 2023 at "Drug discoveries & therapeutics"
DOI: 10.5582/ddt.2022.01109
Abstract: Diminished ovarian reserve (DOR) refers to the decline in fertility caused by the loss of normal ovarian function. DOR is associated with adverse reactions to ovarian stimulation during in vitro fertilization and embryo transfer (IVF-ET),… read more here.
Keywords: ovarian reserve; diminished ovarian; dehydroepiandrosterone; mechanism ... See more keywords