Cover Feature: Regulation of pyruvate dehydrogenase complex related to lactate switch in CHO cells.
Sign Up to like & getrecommendations! Published in 2021 at "Engineering in life sciences"
DOI: 10.1002/elsc.202170027
Abstract: DOI: 10.1002/elsc.202000037 The cover feature visualizes our recent article about the investigation of the regulation of the Pyruvate Dehydrogenase Complex (PDC) during the lactate switch in batch cultures of Chinese Hamster Ovary cells. The relevance… read more here.
Keywords: lactate switch; dehydrogenase complex; regulation pyruvate; cover feature ... See more keywords
Stimulating pyruvate dehydrogenase complex reduces itaconate levels and enhances TCA cycle anabolic bioenergetics in acutely inflamed monocytes
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3a1119-236r
Abstract: The pyruvate dehydrogenase complex (PDC)/pyruvate dehydrogenase kinase (PDK) axis directs the universal survival principles of immune resistance and tolerance in monocytes by controlling anabolic and catabolic energetics. Immune resistance shifts to immune tolerance during inflammatory… read more here.
Keywords: tca cycle; cycle; dehydrogenase complex; pyruvate dehydrogenase ... See more keywords
Restoration of fitness lost due to dysregulation of the pyruvate dehydrogenase complex is triggered by ribosomal binding site modifications
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.108961
Abstract: SUMMARY Pyruvate dehydrogenase complex (PDC) functions as the main determinant of the respiro-fermentative balance because it converts pyruvate to acetyl-coenzyme A (CoA), which then enters the TCA (tricarboxylic acid cycle). PDC is repressed by the… read more here.
Keywords: pdc; dehydrogenase complex; evolved strains; pyruvate dehydrogenase ... See more keywords
MFN2-driven mitochondria-to-nucleus tethering allows a non-canonical nuclear entry pathway of the mitochondrial pyruvate dehydrogenase complex.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular cell"
DOI: 10.1016/j.molcel.2022.02.003
Abstract: The mitochondrial pyruvate dehydrogenase complex (PDC) translocates into the nucleus, facilitating histone acetylation by producing acetyl-CoA. We describe a noncanonical pathway for nuclear PDC (nPDC) import that does not involve nuclear pore complexes (NPCs). Mitochondria cluster… read more here.
Keywords: mitochondria nucleus; dehydrogenase complex; pyruvate dehydrogenase; mitochondrial pyruvate ... See more keywords
Calcineurin inactivation inhibits pyruvate dehydrogenase complex activity and induces the Warburg effect
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DOI: 10.1038/s41388-021-02065-0
Abstract: Calcineurin is a calcium- and calmodulin-dependent serine/threonine protein phosphatase that connects the Ca2+-dependent signalling to multiple cellular responses. Calcineurin inhibitors (CNIs) have been widely used to suppress immune response in allograft patients. However, CNIs significantly… read more here.
Keywords: dehydrogenase complex; calcineurin; warburg effect; cancer ... See more keywords
TGF-β1 is a regulator of the pyruvate dehydrogenase complex in fibroblasts
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DOI: 10.1038/s41598-020-74919-8
Abstract: TGF-β1 reprograms metabolism in renal fibroblasts, inducing a switch from oxidative phosphorylation to aerobic glycolysis. However, molecular events underpinning this are unknown. Here we identify that TGF-β1 downregulates acetyl-CoA biosynthesis via regulation of the pyruvate… read more here.
Keywords: dehydrogenase complex; pdc; tgf; acetyl coa ... See more keywords
Pyruvate dehydrogenase complex deficiency mimicking congenital cytomegalovirus infection on imaging
Sign Up to like & getrecommendations! Published in 2022 at "Baylor University Medical Center Proceedings"
DOI: 10.1080/08998280.2021.1999192
Abstract: Abstract Pyruvate dehydrogenase complex deficiency is a rare and underdiagnosed disease. It can present with clinical manifestations as early as in utero. Both genetic and metabolic testing are available to determine the presence of the… read more here.
Keywords: dehydrogenase complex; complex deficiency; pyruvate dehydrogenase; cytomegalovirus ... See more keywords
Succinate dehydrogenase complex subunit C: Role in cellular physiology and disease
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DOI: 10.1177/15353702221147567
Abstract: Succinate dehydrogenase complex subunit C (SDHC) is a subunit of mitochondrial complex II (MCII), which is also known as succinate dehydrogenase (SDH) or succinate: ubiquinone oxidoreductase. Mitochondrial complex II is the smallest respiratory complex in… read more here.
Keywords: succinate dehydrogenase; physiology; complex subunit; dehydrogenase complex ... See more keywords
Pyruvate dehydrogenase complex deficiency: updating the clinical, metabolic and mutational landscapes in a cohort of Portuguese patients
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DOI: 10.1186/s13023-020-01586-3
Abstract: Background The pyruvate dehydrogenase complex (PDC) catalyzes the irreversible decarboxylation of pyruvate into acetyl-CoA. PDC deficiency can be caused by alterations in any of the genes encoding its several subunits. The resulting phenotype, though very… read more here.
Keywords: dehydrogenase complex; deficiency; portuguese patients; pyruvate dehydrogenase ... See more keywords
The Pyruvate Dehydrogenase Complex in Sepsis: Metabolic Regulation and Targeted Therapy
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DOI: 10.3389/fnut.2021.783164
Abstract: Anaerobic glycolysis is the process by which glucose is broken down into pyruvate and lactate and is the primary metabolic pathway in sepsis. The pyruvate dehydrogenase complex (PDHC) is a multienzyme complex that serves as… read more here.
Keywords: pdhc; sepsis; pyruvate dehydrogenase; metabolic regulation ... See more keywords
Human Serum Mediated Bacteriophage Life Cycle Switch in Aggregatibacter actinomycetemcomitans Is Linked to Pyruvate Dehydrogenase Complex
Sign Up to like & getrecommendations! Published in 2023 at "Life"
DOI: 10.3390/life13020436
Abstract: Antimicrobial resistance is rising as a major global public health threat and antibiotic resistance genes are widely spread among species, including human oral pathogens, e.g., Aggregatibacter actinomycetemcomitans. This Gram-negative, capnophilic, facultative anaerobe is well recognized… read more here.
Keywords: cycle; serum; aggregatibacter actinomycetemcomitans; dehydrogenase complex ... See more keywords