Cover Feature: Regulation of pyruvate dehydrogenase complex related to lactate switch in CHO cells.
Sign Up to like & getrecommendations! Published in 2021 at "Engineering in life sciences"
DOI: 10.1002/elsc.202170027
Abstract: DOI: 10.1002/elsc.202000037 The cover feature visualizes our recent article about the investigation of the regulation of the Pyruvate Dehydrogenase Complex (PDC) during the lactate switch in batch cultures of Chinese Hamster Ovary cells. The relevance… read more here.
Keywords: lactate switch; dehydrogenase complex; regulation pyruvate; cover feature ... See more keywords
Stimulating pyruvate dehydrogenase complex reduces itaconate levels and enhances TCA cycle anabolic bioenergetics in acutely inflamed monocytes
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3a1119-236r
Abstract: The pyruvate dehydrogenase complex (PDC)/pyruvate dehydrogenase kinase (PDK) axis directs the universal survival principles of immune resistance and tolerance in monocytes by controlling anabolic and catabolic energetics. Immune resistance shifts to immune tolerance during inflammatory… read more here.
Keywords: tca cycle; cycle; dehydrogenase complex; pyruvate dehydrogenase ... See more keywords
Restoration of fitness lost due to dysregulation of the pyruvate dehydrogenase complex is triggered by ribosomal binding site modifications
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.108961
Abstract: SUMMARY Pyruvate dehydrogenase complex (PDC) functions as the main determinant of the respiro-fermentative balance because it converts pyruvate to acetyl-coenzyme A (CoA), which then enters the TCA (tricarboxylic acid cycle). PDC is repressed by the… read more here.
Keywords: pdc; dehydrogenase complex; evolved strains; pyruvate dehydrogenase ... See more keywords
MFN2-driven mitochondria-to-nucleus tethering allows a non-canonical nuclear entry pathway of the mitochondrial pyruvate dehydrogenase complex.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular cell"
DOI: 10.1016/j.molcel.2022.02.003
Abstract: The mitochondrial pyruvate dehydrogenase complex (PDC) translocates into the nucleus, facilitating histone acetylation by producing acetyl-CoA. We describe a noncanonical pathway for nuclear PDC (nPDC) import that does not involve nuclear pore complexes (NPCs). Mitochondria cluster… read more here.
Keywords: mitochondria nucleus; dehydrogenase complex; pyruvate dehydrogenase; mitochondrial pyruvate ... See more keywords
Metabolic Engineering of Lactococcus lactis for the Enhanced Production of Lactate by Manipulating Pyruvate Dehydrogenase Complex E2 and Lactate Dehydrogenase.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.5c09688
Abstract: The pyruvate dehydrogenase complex (PDHc) in Lactococcus lactis, composed of pdh E1α, E1β, and E2, links glycolysis to the tricarboxylic acid cycle (TCA cycle). This study investigated the effect of the pdh E2 knockout on… read more here.
Keywords: pyruvate dehydrogenase; lactate; lactis; dehydrogenase ... See more keywords
Parapyruvate Induces Neurodegeneration in C57BL/6JNarl Mice via Inhibition of the α-Ketoglutarate Dehydrogenase Complex
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DOI: 10.1021/acsomega.3c09469
Abstract: Parapyruvate is a substance commonly found in commercial dietary supplements of calcium pyruvate (DSCP) that inhibits the α-ketoglutarate dehydrogenase complex (KGDHC) and has been shown to induce senescence in human Hs68 cells. However, it is… read more here.
Keywords: c57bl 6jnarl; ketoglutarate dehydrogenase; 6jnarl mice; parapyruvate ... See more keywords
Calcineurin inactivation inhibits pyruvate dehydrogenase complex activity and induces the Warburg effect
Sign Up to like & getrecommendations! Published in 2021 at "Oncogene"
DOI: 10.1038/s41388-021-02065-0
Abstract: Calcineurin is a calcium- and calmodulin-dependent serine/threonine protein phosphatase that connects the Ca2+-dependent signalling to multiple cellular responses. Calcineurin inhibitors (CNIs) have been widely used to suppress immune response in allograft patients. However, CNIs significantly… read more here.
Keywords: dehydrogenase complex; calcineurin; warburg effect; cancer ... See more keywords
TGF-β1 is a regulator of the pyruvate dehydrogenase complex in fibroblasts
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DOI: 10.1038/s41598-020-74919-8
Abstract: TGF-β1 reprograms metabolism in renal fibroblasts, inducing a switch from oxidative phosphorylation to aerobic glycolysis. However, molecular events underpinning this are unknown. Here we identify that TGF-β1 downregulates acetyl-CoA biosynthesis via regulation of the pyruvate… read more here.
Keywords: dehydrogenase complex; pdc; tgf; acetyl coa ... See more keywords
Pyruvate dehydrogenase complex deficiency mimicking congenital cytomegalovirus infection on imaging
Sign Up to like & getrecommendations! Published in 2022 at "Baylor University Medical Center Proceedings"
DOI: 10.1080/08998280.2021.1999192
Abstract: Abstract Pyruvate dehydrogenase complex deficiency is a rare and underdiagnosed disease. It can present with clinical manifestations as early as in utero. Both genetic and metabolic testing are available to determine the presence of the… read more here.
Keywords: dehydrogenase complex; complex deficiency; pyruvate dehydrogenase; cytomegalovirus ... See more keywords
Manifestations of X‐linked pyruvate dehydrogenase complex deficiency in female PDHA1 carriers
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DOI: 10.1111/ene.16283
Abstract: Pyruvate dehydrogenase complex deficiency is in up to 90% caused by pathogenic variants in the X‐linked PDHA1 gene. We aimed to investigate female relatives of index patients with PDHA1‐related disease to (i) describe the prevalence… read more here.
Keywords: female pdha1; pdha1 carriers; pyruvate dehydrogenase; complex deficiency ... See more keywords
Pyruvate dehydrogenase complex component B: A Gene Associated with Cuproptosis and Encoding the Beta Subunit of Pyruvate Dehydrogenase Is Involved in the Oxidative Decarboxylation Reaction.
Sign Up to like & getrecommendations! Published in 2025 at "DNA and cell biology"
DOI: 10.1177/10445498251365934
Abstract: Cuproptosis is a regulated cell death mechanism that has recently been identified and is distinct from other known cell death mechanisms (e.g., apoptosis, Ferroptosis, necrotic apoptosis, etc.). Cuproptosis causes oligomer formation through the abnormal accumulation… read more here.
Keywords: complex component; cuproptosis; pyruvate dehydrogenase; dehydrogenase ... See more keywords