R132 mutations in canine isocitrate dehydrogenase 1 (IDH1) lead to functional changes
Sign Up to like & getrecommendations! Published in 2017 at "Veterinary Research Communications"
DOI: 10.1007/s11259-017-9707-8
Abstract: Glioma is the second most common intracranial neoplasia in dogs, but the pathogenic mechanisms remain unclear. In humans, isocitrate dehydrogenase 1 (IDH1) is frequently mutated in gliomas. Although almost all human IDH1 mutations have been… read more here.
Keywords: r132h; isocitrate dehydrogenase; dehydrogenase idh1; r132s ... See more keywords
Capturing the Dynamic Conformational Changes of Human Isocitrate Dehydrogenase 1 (IDH1) upon Ligand and Metal Binding Using Hydrogen-Deuterium Exchange Mass Spectrometry.
Sign Up to like & getrecommendations! Published in 2023 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00636
Abstract: Human isocitrate dehydrogenase 1 (IDH1) is a highly conserved metabolic enzyme that catalyzes the interconversion of isocitrate and α-ketoglutarate. Kinetic and structural studies with IDH1 have revealed evidence of striking conformational changes that occur upon… read more here.
Keywords: dehydrogenase idh1; isocitrate dehydrogenase; conformational changes; human isocitrate ... See more keywords