Fragment-Based Approach to Targeting Inosine-5′-monophosphate Dehydrogenase (IMPDH) from Mycobacterium tuberculosis
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DOI: 10.1021/acs.jmedchem.7b01622
Abstract: Tuberculosis (TB) remains a major cause of mortality worldwide, and improved treatments are needed to combat emergence of drug resistance. Inosine 5′-monophosphate dehydrogenase (IMPDH), a crucial enzyme required for de novo synthesis of guanine nucleotides,… read more here.
Keywords: monophosphate dehydrogenase; impdh; fragment based; inosine monophosphate ... See more keywords