Bioactivity screening, extraction, and separation of lactate dehydrogenase inhibitors from Polygala tenuifolia Willd. based on a hyphenated strategy.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of separation science"
DOI: 10.1002/jssc.201601216
Abstract: Stroke is the second leading cause of death worldwide. Lactate dehydrogenase inhibitors are currently widely used in the treatment of ischemic stroke, and natural products are considered promising sources of lactate dehydrogenase inhibitors. In this… read more here.
Keywords: extraction; lactate dehydrogenase; dehydrogenase inhibitors; separation ... See more keywords
Rational Design, Synthesis, and Biological Evaluation of Fluorine- and Chlorine-Substituted Pyrazol-5-yl-benzamide Derivatives as Potential Succinate Dehydrogenase Inhibitors.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c01901
Abstract: To develop novel succinate dehydrogenase inhibitors (SDHIs), two series of novel N-4-fluoro-pyrazol-5-yl-benzamide and N-4-chloro-pyrazol-5-yl-benzamide derivatives were designed and synthesized, and their antifungal activities were evaluated against Valsa mali, Sclerotinia sclerotiorum, FusaHum graminearum Sehw, Physalospora piricola,… read more here.
Keywords: pyrazol benzamide; compound 9ip; dehydrogenase inhibitors; benzamide derivatives ... See more keywords
Dihydroorotate dehydrogenase inhibitors in SARS‐CoV‐2 infection
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DOI: 10.1111/eci.13366
Abstract: Since late 2019, a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral outbreak has spread all over the world. The disease caused by SARS-CoV-2, named COVID-19, has caused over 550,000 deaths and infected close to… read more here.
Keywords: dehydrogenase inhibitors; inhibitors sars; sars cov; cov infection ... See more keywords
Mutant Isocitrate Dehydrogenase Inhibitors as Targeted Cancer Therapeutics
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DOI: 10.3389/fonc.2019.00417
Abstract: The identification of heterozygous neomorphic isocitrate dehydrogenase (IDH) mutations across multiple cancer types including both solid and hematologic malignancies has revolutionized our understanding of oncogenesis in these malignancies and the potential for targeted therapeutics using… read more here.
Keywords: dehydrogenase; dehydrogenase inhibitors; mutant isocitrate; isocitrate dehydrogenase ... See more keywords