Bioactivity screening, extraction, and separation of lactate dehydrogenase inhibitors from Polygala tenuifolia Willd. based on a hyphenated strategy.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of separation science"
DOI: 10.1002/jssc.201601216
Abstract: Stroke is the second leading cause of death worldwide. Lactate dehydrogenase inhibitors are currently widely used in the treatment of ischemic stroke, and natural products are considered promising sources of lactate dehydrogenase inhibitors. In this… read more here.
Keywords: extraction; lactate dehydrogenase; dehydrogenase inhibitors; separation ... See more keywords
Rational Design, Synthesis, and Biological Evaluation of Fluorine- and Chlorine-Substituted Pyrazol-5-yl-benzamide Derivatives as Potential Succinate Dehydrogenase Inhibitors.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c01901
Abstract: To develop novel succinate dehydrogenase inhibitors (SDHIs), two series of novel N-4-fluoro-pyrazol-5-yl-benzamide and N-4-chloro-pyrazol-5-yl-benzamide derivatives were designed and synthesized, and their antifungal activities were evaluated against Valsa mali, Sclerotinia sclerotiorum, FusaHum graminearum Sehw, Physalospora piricola,… read more here.
Keywords: pyrazol benzamide; compound 9ip; dehydrogenase inhibitors; benzamide derivatives ... See more keywords
Comprehensive Overview of the Amide Linker Modification in the Succinate Dehydrogenase Inhibitors.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.4c05854
Abstract: Succinate dehydrogenase inhibitors (SDHIs) have become one of the most important classes of agrochemical fungicides. According to the data from FRAC, the resistance risk for SDHIs had reached up to medium and even to high.… read more here.
Keywords: succinate dehydrogenase; amide linker; dehydrogenase inhibitors; linker ... See more keywords
3D-QSAR-Guided Molecule Design and Protein-Ligand Interaction Studies for Discovery of Succinate Dehydrogenase Inhibitors.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.5c03093
Abstract: Succinate dehydrogenase (SDH) is an ideal fungicidal target. Here, a three-dimensional quantitative structure-activity relationship (3D-QSAR) was established based on the data of 74 compounds with activity against Rhizoctonia solani. By integrating our previously reported 3D-QSAR… read more here.
Keywords: succinate dehydrogenase; guided molecule; dehydrogenase inhibitors; qsar guided ... See more keywords
Discovery of Highly Efficient Novel Potential Succinate Dehydrogenase Inhibitors Containing a Stilbene Group for Management of Sheath Blight of Rice and Sclerotinia Stem Rot of Oilseed Rape.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.5c03978
Abstract: In the search for novel succinate dehydrogenase inhibitors (SDHIs) fungicides for managing rice sheath blight (RSB) and sclerotinia stem rot (SSR), 28 pyrazole-4-carboxamides incorporating stilbene or diphenylacetylene scaffolds were synthesized and evaluated for antifungal activities.… read more here.
Keywords: succinate dehydrogenase; dehydrogenase inhibitors; sheath blight; stem rot ... See more keywords
In Pursuit of Lead Innovation: Pharmaceutically Important and Distinct Amide-Free Succinate Dehydrogenase Inhibitors.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.4c02757
Abstract: Though succinate dehydrogenase inhibitors (SDHIs) are quite successful in the modern agrochemical industry, the Fungicide Resistance Action Committee has classified the resistance risk as "medium to high". Structural analysis reveals that these antifungal chemotypes are… read more here.
Keywords: succinate dehydrogenase; resistance; dehydrogenase inhibitors; lead innovation ... See more keywords
Novel Succinate Dehydrogenase Inhibitors Containing Oxime Ester Structures: Design, Synthesis, and Biological Activities
Sign Up to like & getrecommendations! Published in 2025 at "New Journal of Chemistry"
DOI: 10.1039/d5nj02547h
Abstract: The development of succinate dehydrogenase inhibitors (SDHIs) is crucial for ensuring sustainable food production. This study introduces a novel class of aryl oxime ester derivatives to improve antifungal activity. In vitro experiments... read more here.
Keywords: succinate dehydrogenase; inhibitors containing; dehydrogenase inhibitors; oxime ester ... See more keywords
Dihydroorotate dehydrogenase inhibitors in SARS‐CoV‐2 infection
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Clinical Investigation"
DOI: 10.1111/eci.13366
Abstract: Since late 2019, a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral outbreak has spread all over the world. The disease caused by SARS-CoV-2, named COVID-19, has caused over 550,000 deaths and infected close to… read more here.
Keywords: dehydrogenase inhibitors; inhibitors sars; sars cov; cov infection ... See more keywords
Mutant Isocitrate Dehydrogenase Inhibitors as Targeted Cancer Therapeutics
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DOI: 10.3389/fonc.2019.00417
Abstract: The identification of heterozygous neomorphic isocitrate dehydrogenase (IDH) mutations across multiple cancer types including both solid and hematologic malignancies has revolutionized our understanding of oncogenesis in these malignancies and the potential for targeted therapeutics using… read more here.
Keywords: dehydrogenase; dehydrogenase inhibitors; mutant isocitrate; isocitrate dehydrogenase ... See more keywords
Comparing Isocitrate Dehydrogenase Inhibitors with Procarbazine, Lomustine, and Vincristine Chemotherapy for Oligodendrogliomas
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DOI: 10.3390/cancers17233880
Abstract: Simple Summary Oligodendroglioma is an uncommon brain tumor that often affects younger and middle-aged adults and can progress slowly over many years. The current treatment approach relies on surgery followed by radiation and a three-drug… read more here.
Keywords: procarbazine lomustine; comparing isocitrate; dehydrogenase inhibitors; isocitrate dehydrogenase ... See more keywords