Pyruvate dehydrogenase kinase 4 promotes ubiquitin–proteasome system‐dependent muscle atrophy
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.13100
Abstract: Muscle atrophy, leading to muscular dysfunction and weakness, is an adverse outcome of sustained period of glucocorticoids usage. However, the molecular mechanism underlying this detrimental condition is currently unclear. Pyruvate dehydrogenase kinase 4 (PDK4), a… read more here.
Keywords: muscle atrophy; pyruvate dehydrogenase; muscle; dehydrogenase kinase ... See more keywords
Anticancer effects of some novel dichloroacetophenones through the inhibition of pyruvate dehydrogenase kinase 1
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2018.07.026
Abstract: ABSTRACT Targeting pyruvate dehydrogenase kinase 1 (PDK1) has been suggested as a potential anticancer strategy. 2,2‐dichloroacetophenone (DAP) is a PDK1 inhibitor exhibiting weak anticancer potency and poor selectivity. The current study describes the characterization of… read more here.
Keywords: dehydrogenase; dehydrogenase kinase; pdk1; anticancer ... See more keywords
Investigation of inhibitory potential of quercetin to the pyruvate dehydrogenase kinase 3: Towards implications in anticancer therapy.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.06.158
Abstract: Pyruvate dehydrogenase kinase 3 (PDK3) is a mitochondrial protein, has recently been considered as a potential pharmacological target for varying types of cancer and diabetes. Here, we report the binding mechanism of quercetin to the… read more here.
Keywords: quercetin pdk3; dehydrogenase kinase; quercetin; pdk3 ... See more keywords
ARNT deficiency represses pyruvate dehydrogenase kinase 1 to trigger ROS production and melanoma metastasis
Sign Up to like & getrecommendations! Published in 2021 at "Oncogenesis"
DOI: 10.1038/s41389-020-00299-3
Abstract: The metabolic changes in melanoma cells that are required for tumor metastasis have not been fully elucidated. In this study, we show that the increase in glucose uptake and mitochondrial oxidative phosphorylation confers metastatic ability… read more here.
Keywords: metastasis; dehydrogenase kinase; arnt deficiency; deficiency ... See more keywords
Reduction of mitochondria and up regulation of pyruvate dehydrogenase kinase 4 of skeletal muscle in patients with chronic kidney disease
Sign Up to like & getrecommendations! Published in 2019 at "Nephrology"
DOI: 10.1111/nep.13606
Abstract: Muscle weakness is commonly among chronic kidney disease (CKD) patients. Muscle mitochondrial dysfunction and decreased pyruvate dehydrogenase (PDH) activity occur in CKD animals but have not been confirmed in humans, and changes in pyruvate dehydrogenase… read more here.
Keywords: pyruvate dehydrogenase; chronic kidney; muscle; dehydrogenase kinase ... See more keywords
Farnesoid X Receptor Deficiency Induces Hepatic Lipid and Glucose Metabolism Disorder via Regulation of Pyruvate Dehydrogenase Kinase 4
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/3589525
Abstract: Farnesoid X receptors (FXR) are bile acid receptors that play roles in lipid, glucose, and energy homeostasis. Synthetic FXR-specific agonists have been developed for treating nonalcoholic fatty liver disease (NAFLD) patients. However, the detailed mechanism… read more here.
Keywords: dehydrogenase kinase; metabolism disorder; pyruvate dehydrogenase; glucose metabolism ... See more keywords
Elevated Level of Cerebrospinal Fluid Pyruvate Dehydrogenase Kinase 4 Is a Predictive Biomarker of Clinical Outcome after Subarachnoid Hemorrhage
Sign Up to like & getrecommendations! Published in 2022 at "Brain Sciences"
DOI: 10.3390/brainsci12111507
Abstract: Subarachnoid hemorrhage (SAH) is a central nervous system disease with high mortality and morbidity. Some independent factors valuable for prognosis prediction in patients with SAH are still lacking. In our earlier study, we found that… read more here.
Keywords: hemorrhage; subarachnoid hemorrhage; cerebrospinal fluid; dehydrogenase kinase ... See more keywords
Suppression of Pyruvate Dehydrogenase Kinase by Dichloroacetate in Cancer and Skeletal Muscle Cells Is Isoform Specific and Partially Independent of HIF-1α
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22168610
Abstract: Inhibition of pyruvate dehydrogenase kinase (PDK) emerged as a potential strategy for treatment of cancer and metabolic disorders. Dichloroacetate (DCA), a prototypical PDK inhibitor, reduces the abundance of some PDK isoenzymes. However, the underlying mechanisms… read more here.
Keywords: pdk; skeletal muscle; muscle cells; dehydrogenase kinase ... See more keywords
Pyruvate Dehydrogenase Kinase Inhibition by Dichloroacetate in Melanoma Cells Unveils Metabolic Vulnerabilities
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23073745
Abstract: Melanoma is characterized by high glucose uptake, partially mediated through elevated pyruvate dehydrogenase kinase (PDK), making PDK a potential treatment target in melanoma. We aimed to reduce glucose uptake in melanoma cell lines through PDK… read more here.
Keywords: inhibition; melanoma; metabolic vulnerabilities; dehydrogenase kinase ... See more keywords