Isocitrate dehydrogenase‐mutant glioma: Evolving clinical and therapeutic implications
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DOI: 10.1002/cncr.31039
Abstract: The metabolic genes isocitrate dehydrogenase 1 (IDH1) and IDH2 are commonly mutated in low‐grade glioma and in a subset of glioblastoma. These mutations co‐occur with other recurrent molecular alterations, including 1p/19q codeletions and tumor suppressor… read more here.
Keywords: glioma; isocitrate dehydrogenase; idh; mutant glioma ... See more keywords
Therapeutic targeting of isocitrate dehydrogenase mutant AML
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DOI: 10.1080/13543784.2017.1317745
Abstract: The last decade has witnessed rapid advances in our understanding of molecular leukemogenesis providing valuable insights from which to explore new therapeutic avenues. Characterization of the muta... read more here.
Keywords: isocitrate dehydrogenase; therapeutic targeting; mutant aml; targeting isocitrate ... See more keywords