Synthesis and In Vitro Biological Evaluation of Quinolinyl Pyrimidines Targeting Type II NADH-Dehydrogenase (NDH-2)
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DOI: 10.1021/acsinfecdis.1c00413
Abstract: Type II NADH dehydrogenase (NDH-2) is an essential component of electron transfer in many microbial pathogens but has remained largely unexplored as a potential drug target. Previously, quinolinyl pyrimidines were shown to inhibit Mycobacterium tuberculosis… read more here.
Keywords: quinolinyl pyrimidines; type nadh; nadh dehydrogenase; dehydrogenase ndh ... See more keywords