Tunable Toxicity of Bufadienolides is Regulated through a Configuration Inversion Catalyzed by a Short‐Chain Dehydrogenase/Reductase
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DOI: 10.1002/cbic.202200473
Abstract: Bufadienolides are toxic components widely found in amphibious toads that exhibit a wide range of biological activities. Guided by UPLC‐QTOF‐MS analysis, several 3‐epi‐bufadienolides with unique structures were isolated from the bile of the Asiatic toad,… read more here.
Keywords: dehydrogenase reductase; short chain; chain dehydrogenase; toxicity ... See more keywords
Overexpression of Dehydrogenase/Reductase 9 Predicts Poor Response to Concurrent Chemoradiotherapy and Poor Prognosis in Rectal Cancer Patients
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DOI: 10.3389/pore.2022.1610537
Abstract: Objective: To reduce the risk of locoregional recurrence, the addition of neoadjuvant concurrent chemoradiotherapy (CCRT) is recommended before surgical management for rectal cancer patients. However, despite identical tumor histology, individual patient response to neoadjuvant CCRT… read more here.
Keywords: cancer patients; dehydrogenase reductase; concurrent chemoradiotherapy; rectal cancer ... See more keywords