Natural α,β-unsaturated lactones inhibit neuropeptide-induced mast cell activation in an in vitro model of neurogenic inflammation
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DOI: 10.1007/s00011-020-01380-8
Abstract: Mast cells are involved in not only inducing, but also maintaining neurogenic inflammation and neuropathic pain. In previous work, we have demonstrated that dehydroleucodine, xanthatin and 3-benzyloxymethyl-5H-furan-2-one inhibit rat peritoneal and human LAD2 mast cell… read more here.
Keywords: mast; dehydroleucodine xanthatin; neurogenic inflammation; mast cell ... See more keywords
Effect of a Cytoprotective Dose of Dehydroleucodine, Xanthatin, and 3-Benzyloxymethyl-5H-furan-2-one on Gastric Mucosal Lesions Induced by Mast Cell Activation
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DOI: 10.3390/ijms22115983
Abstract: The aim of this study was to determine whether the lactones dehydroleucodine, xanthatin and 3-benzyloxymethyl-5H-furan-2-one, would be effective in an animal model of gastric ulcer induced by mast cell activation. Rats were divided into ten… read more here.
Keywords: cell activation; cell; dehydroleucodine xanthatin; mast cell ... See more keywords