IMB-T130 targets 3-dehydroquinate synthase and inhibits Mycobacterium tuberculosis
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-35701-z
Abstract: The anti-tuberculosis (TB) agent IMB-T130 was speculated to be a multi-target compound. In this research, we found that IMB-T130 inhibits the catalytic activity of Mycobacterium tuberculosis 3-dehydroquinate synthase (MtDHQS), the enzyme in the second step… read more here.
Keywords: dehydroquinate synthase; imb; imb t130; mycobacterium tuberculosis ... See more keywords
Dehydroquinate Synthase Directly Binds to Streptomycin and Regulates Susceptibility of Mycobacterium bovis to Streptomycin in a Non-canonical Mode
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.818881
Abstract: Antimicrobial resistance (AMR) represents one of the main challenges in Tuberculosis (TB) treatment. Investigating the genes involved in AMR and the underlying mechanisms holds promise for developing alternative treatment strategies. The results indicate that dehydroquinate… read more here.
Keywords: regulates susceptibility; binds streptomycin; susceptibility mycobacterium; dehydroquinate synthase ... See more keywords