Synthesis and Biological Evaluation of an Indazole-Based Selective Protein Arginine Deiminase 4 (PAD4) Inhibitor.
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DOI: 10.1021/acsmedchemlett.8b00283
Abstract: Protein arginine deiminase 4 (PAD4) is a calcium-dependent enzyme that catalyzes the conversion of arginine to citrulline within target proteins. Dysregulation of PAD4 has been implicated in a number of human diseases, including rheumatoid arthritis… read more here.
Keywords: pad4 inhibitor; pad4; protein arginine; arginine deiminase ... See more keywords