The role of the halogen bond in iodothyronine deiodinase: Dependence on chalcogen substitution in naphthyl‐based mimetics
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Computational Chemistry"
DOI: 10.1002/jcc.25775
Abstract: The effects on the activity of thyroxine (T4) due to the chalcogen replacement in a series of peri‐substituted naphthalenes mimicking the catalytic function of deiodinase enzymes are computationally examined using density functional theory. In particular,… read more here.
Keywords: deiodinase; naphthyl based; halogen bond; chalcogen ... See more keywords
The transcription of iodothyronine deiodinase genes is regulated by thyroid hormone receptor in the Pacific oyster Crassostrea gigas
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Oceanology and Limnology"
DOI: 10.1007/s00343-019-8207-9
Abstract: Thyroid hormones (THs) are indispensable for each phyla in Chordata, while their functions in the non-chordate invertebrates are indistinct. Studies on the TH system in non-chordate invertebrates are important for understanding the evolution of TH… read more here.
Keywords: oyster crassostrea; transcription; pacific oyster; oyster ... See more keywords
Deiodinases in thyroid tumorigenesis
Sign Up to like & getrecommendations! Published in 2023 at "Endocrine-Related Cancer"
DOI: 10.1530/erc-23-0015
Abstract: The three deiodinase selenoenzymes are key regulators of intracellular thyroid hormone (TH) levels. The two TH-activating deiodinases (type 1 deiodinase and type 2 deiodinase (D2)) are normally expressed in follicular thyroid cells and contribute to… read more here.
Keywords: thyroid cancers; type deiodinase; thyroid tumorigenesis; deiodinase ... See more keywords
Biotransformation of Dec-604 and potential effect on thyroid deiodinase activity in highly flame retardant-exposed gulls.
Sign Up to like & getrecommendations! Published in 2022 at "Environmental research"
DOI: 10.2139/ssrn.4126069
Abstract: Several halogenated flame retardants (HFRs) have been identified as thyroid disruptors in birds including the polybrominated diphenyl ether (PBDE) mixtures, which have been replaced with other HFRs such as Dechlorane-604 (Dec-604). Dec-604 Component B (Dec-604… read more here.
Keywords: effect; dio1; deiodinase; activity ... See more keywords
Deiodinases and the Three Types of Thyroid Hormone Deiodination Reactions
Sign Up to like & getrecommendations! Published in 2021 at "Endocrinology and Metabolism"
DOI: 10.3803/enm.2021.1198
Abstract: Thyroid hormone (TH) signaling is strictly regulated by iodothyronine deiodinase activity, which both preserves the circulating levels of the biologically active triiodothyronine (T3) and regulates TH homeostasis at the local level, in a cell- and… read more here.
Keywords: three types; types thyroid; deiodinases three; deiodinase ... See more keywords