Prevalence and timing of TP53 mutations in del(17p) myeloma and effect on survival
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DOI: 10.1038/bcj.2017.76
Abstract: The recent remarkable advances in multiple myeloma (MM) therapy and outcomes have had mixed impact on patients with adverse risk genetics, many of whom continue to have inferior outcomes. This applies particularly to deletion of… read more here.
Keywords: del 17p; timing tp53; prevalence timing; tp53 mutations ... See more keywords
Imaging flow cytometric detection of del(17p) in bone marrow and circulating plasma cells in multiple myeloma
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Laboratory Hematology"
DOI: 10.1111/ijlh.14248
Abstract: Detection of del(17p) in myeloma is generally performed by fluorescence in situ hybridization (FISH) on a slide with analysis of up to 200 nuclei. The small cell sample analyzed makes this a low precision test.… read more here.
Keywords: detection del; 17p bone; del 17p; bone marrow ... See more keywords
Detection of Clinically Relevant Molecular Alterations in Chronic Lymphocytic Leukemia (CLL) By Nanopore Sequencing
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-110948
Abstract: Introduction Chronic Lymphocytic Leukaemia (CLL) is the most prevalent leukaemia in the Western world and characterised by clinical heterogeneity. IgHV mutation status, mutations in the TP53 gene and deletions of the p-arm of chromosome 17… read more here.
Keywords: sample; cll; detection; del 17p ... See more keywords
Impact of Acquired Del(17p) in Patients with Multiple Myeloma
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DOI: 10.1182/blood-2018-99-115458
Abstract: Introduction Del(17p) detected by fluorescence in situ hybridisation (FISH) of bone marrow plasma cells (BMPCs) is an adverse prognostic factor in patients with multiple myeloma (MM). While the natural history and prognostic factors in patients… read more here.
Keywords: del 17p; research; membership entity; research funding ... See more keywords
Clinical Course of High-Risk Multiple Myeloma Patients in Korea: A Multicenter Retrospective Study
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DOI: 10.1182/blood-2020-136242
Abstract: Introduction: Increased understanding of the pathophysiology of multiple myeloma (MM) and the introduction of new drugs has led to considerable survival improvements in recent years. The International Myeloma Working Group consensus recently updated the definition… read more here.
Keywords: high risk; del 17p; research funding;
Baseline clinical characteristics of patients with chronic lymphocytic leukemia (CLL) from 11 Latin American countries: A real-world registry analysis
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DOI: 10.1182/blood-2025-3908
Abstract: Background: Chronic lymphocytic leukemia (CLL) exhibits diverse clinical manifestations, and access to diagnostic and staging tools varies significantly throughout Latin America (LATAM). To improve our understanding of how the disease presents and how it is… read more here.
Keywords: stage stage; registry; stage; chronic lymphocytic ... See more keywords
Outcomes of multiple myeloma (MM) patients with del 17p as a sole high risk cytogenetic abnormality who underwent either single or tandem upfront autologous stem cell transplant approaches in EBMT centres between 2016 and 2022
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DOI: 10.1182/blood-2025-4583
Abstract: Introduction Approximately 10% of patients with newly diagnosed multiple myeloma (MM) have the FISH cytogenetic abnormality, Del 17p, of whom one fifth also have t(4;14) or t(14;16), these additional translocations being associated with worse survival… read more here.
Keywords: tandem asct; tandem; transplant; high risk ... See more keywords
Acquired Chromosomal Abnormalities t(14;16), Del(17p) or Del(13q) after Receiving Chemotherapies Predict the Poor Prognosis of Multiple Myeloma
Sign Up to like & getrecommendations! Published in 2017 at "Blood"
DOI: 10.1182/blood.v130.suppl_1.3116.3116
Abstract: Introduction: Multiple myeloma (MM) is known as heterogeneous disease characterized by the clonal proliferation of tumor plasma cells. Recently, the prognosis of MM is classified depending on the appearance of cytogenetic abnormalities. However, no publication… read more here.
Keywords: del 17p; 17p del; prognosis; del 13q ... See more keywords
17p deletion strongly influences rituximab elimination in chronic lymphocytic leukemia
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DOI: 10.1186/s40425-019-0509-0
Abstract: Chronic lymphocytic leukemia (CLL) is the most common type of leukemia and the anti-CD20 monoclonal antibody, rituximab, represents the therapeutic gold standard for more than 2 decades in this pathology, when used in combination with… read more here.
Keywords: rituximab; del 17p; lymphocytic leukemia; chronic lymphocytic ... See more keywords
Clinical features of patients with multiple myeloma harboring t(4;14) and impact on long-term survival.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2022.40.16_suppl.8062
Abstract: 8062 Background: Translocation (4;14) is a known adverse prognostic factor in myeloma. However, utilization of proteasome inhibitors (PIs) in myeloma has abrogated the negative impact of t(4;14) in myeloma, and some investigators question whether t(4;14)… read more here.
Keywords: long term; maintenance; del 17p; impact ... See more keywords
Meta-analysis of the efficacy of treatments for newly diagnosed and relapsed/refractory multiple myeloma with del(17p).
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.18722
Abstract: We analyzed the treatment of newly diagnosed and relapsed/refractory multiple myeloma (NDMM/RRMM) patients with del(17p). Thirteen prospective studies that evaluated 3,187 MM patients, including 685with del(17p), were included in our meta-analysis. The incidence of del(17p)… read more here.
Keywords: del 17p; newly diagnosed; rrmm patients; dexamethasone ... See more keywords