Delafloxacin Pharmacokinetics in Subjects With Varying Degrees of Renal Function
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Pharmacology"
DOI: 10.1002/jcph.1041
Abstract: Delafloxacin, a fluoroquinolone, has activity against gram‐positive organisms including methicillin‐resistant Staphylococcus aureus and fluoroquinolone‐susceptible and –resistant gram‐negative organisms. This study was conducted to determine delafloxacin pharmacokinetics after a single intravenous infusion or oral dose administration… read more here.
Keywords: subjects varying; clearance; renal function; delafloxacin pharmacokinetics ... See more keywords
The Pharmacokinetics of the CYP3A Substrate Midazolam After Steady-state Dosing of Delafloxacin.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical therapeutics"
DOI: 10.1016/j.clinthera.2017.04.009
Abstract: PURPOSE Delafloxacin is a novel anionic fluoroquinolone in Phase III development for the treatment of serious skin infections. The objective of this study was to evaluate the effects of delafloxacin on the pharmacokinetics of midazolam,… read more here.
Keywords: midazolam; state dosing; steady state; dosing delafloxacin ... See more keywords
Activity of Delafloxacin and Levofloxacin against Stenotrophomonas maltophilia at Simulated Plasma and Intrapulmonary pH Values
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DOI: 10.1128/spectrum.02705-21
Abstract: Stenotrophomonas maltophilia most often infects the lungs, where the physiologic environment is naturally slightly acidic (pH ~6.6), compared to most parts of the body (such as the bloodstream), which have neutral pH values (~7.4). Pneumonia… read more here.
Keywords: environment; levofloxacin; stenotrophomonas maltophilia; delafloxacin ... See more keywords
Development of Lipomer Nanoparticles for the Enhancement of Drug Release, Anti-Microbial Activity and Bioavailability of Delafloxacin
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DOI: 10.3390/pharmaceutics12030252
Abstract: Delafloxacin (DFL) is a novel potent and broad-spectrum fluoroquinolone group of antibiotics effective against both Gram-positive and negative aerobic and anaerobic bacteria. In this study, DFL-loaded stearic acid (lipid) chitosan (polymer) hybrid nanoparticles (L-P-NPs) have… read more here.
Keywords: drug; loaded nps; dfl loaded; delafloxacin ... See more keywords