Delayed puberty and abnormal anthropometry and its associations with quality of life in young Fontan survivors: A multicenter cross‐sectional study
Sign Up to like & getrecommendations! Published in 2018 at "Congenital Heart Disease"
DOI: 10.1111/chd.12597
Abstract: INTRODUCTION We sought to evaluate the prevalence of delayed puberty and abnormal anthropometry and its association with quality of life (QoL) in young Fontan survivors. METHODS This was a cross-sectional study at 11 Pediatric Heart… read more here.
Keywords: delayed puberty; puberty abnormal; abnormal anthropometry; fontan survivors ... See more keywords
Prevalence of delayed puberty and low bone density in patients with epidermolysis bullosa: Insight from a large single center's experience
Sign Up to like & getrecommendations! Published in 2022 at "Pediatric Dermatology"
DOI: 10.1111/pde.15136
Abstract: Epidermolysis bullosa (EB) is a group of rare genetic skin conditions that result in skin fragility. EB can be quite severe with chronic inflammation and malnutrition impairing growth and pubertal development. These factors have potential… read more here.
Keywords: puberty low; low bone; epidermolysis bullosa; delayed puberty ... See more keywords
Delayed puberty in boys in central Sweden: an observational study on diagnosing and management in clinical practice
Sign Up to like & getrecommendations! Published in 2022 at "BMJ Open"
DOI: 10.1136/bmjopen-2021-057088
Abstract: Objectives To compare the usefulness of the classical definition of delayed puberty (DP) in boys with puberty nomograms and to describe the management of DP in boys in a hospital-based setting. Study design Observational retrospective… read more here.
Keywords: study; delayed puberty; puberty boys; central sweden ... See more keywords
Delayed puberty phenotype observed in Noonan syndrome is more pronounced in girls than boys.
Sign Up to like & getrecommendations! Published in 2022 at "Hormone research in paediatrics"
DOI: 10.1159/000522670
Abstract: INTRODUCTION Pubertal delay is described as one of the clinical features in Noonan Syndrome (NS) and it may be one of the factors causing short adult height in those patients. The present study aims at… read more here.
Keywords: age; delayed puberty; pubertal delay; noonan syndrome ... See more keywords
LGR4 deficiency results in delayed puberty through impaired Wnt/β-catenin signaling
Sign Up to like & getrecommendations! Published in 2020 at "JCI Insight"
DOI: 10.1172/jci.insight.133434
Abstract: The initiation of puberty is driven by an upsurge in hypothalamic gonadotropin-releasing hormone (GnRH) secretion. In turn, GnRH secretion upsurge depends on the development of a complex GnRH neuroendocrine network during embryonic life. Although delayed… read more here.
Keywords: catenin signaling; gnrh; delayed puberty; wnt catenin ... See more keywords
Divergent responses to kisspeptin in children with delayed puberty.
Sign Up to like & getrecommendations! Published in 2018 at "JCI insight"
DOI: 10.1172/jci.insight.99109
Abstract: BACKGROUND The neuropeptide kisspeptin stimulates luteinizing hormone (LH) secretion in healthy adults but not in adults with idiopathic hypogonadotropic hypogonadism. We hypothesized that, in children presenting with delayed or stalled puberty, kisspeptin would elicit LH… read more here.
Keywords: delayed puberty; responses kisspeptin; children delayed; response ... See more keywords
Discovery of GnIH and Its Role in Hypothyroidism-Induced Delayed Puberty
Sign Up to like & getrecommendations! Published in 2018 at "Endocrinology"
DOI: 10.1210/en.2017-00300
Abstract: It is known that hypothyroidism delays puberty in mammals. Interaction between the hypothalamo-pituitary-thyroid (HPT) and hypothalamo-pituitary-gonadal (HPG) axes may be important processes in delayed puberty. Gonadotropin-inhibitory hormone (GnIH) is a newly discovered hypothalamic neuropeptide that… read more here.
Keywords: hypothyroidism; thyroid dysfunction; induced thyroid; delayed puberty ... See more keywords
Hypothalamic Overexpression of Makorin Ring Finger Protein 3 Results in Delayed Puberty in Female Mice.
Sign Up to like & getrecommendations! Published in 2022 at "Endocrinology"
DOI: 10.1210/endocr/bqac132
Abstract: Makorin Ring Finger Protein 3 (MKRN3) is an important neuroendocrine player in the control of pubertal timing and upstream inhibitor of GnRH secretion. In mice, expression of Mkrn3 in the hypothalamic arcuate and anteroventral periventricular… read more here.
Keywords: ring finger; makorin ring; finger protein; mice ... See more keywords
Clinical profile and aetiologies of delayed puberty: a 15 years’ experience from a tertiary centre in Sudan
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Pediatric Endocrinology and Metabolism"
DOI: 10.1515/jpem-2022-0243
Abstract: Abstract Objectives Delayed puberty is a common presentation to endocrine clinics, with adult height, sexual capability and fertility being the main concerns for the child and his/her family. Presentation is variable including short stature and/or… read more here.
Keywords: endocrinology; short stature; puberty; delayed puberty ... See more keywords
Genetic analysis of failed male puberty using whole exome sequencing
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Pediatric Endocrinology and Metabolism"
DOI: 10.1515/jpem-2022-0254
Abstract: Abstract Objectives Although at least 598 genes are involved in the development of the hypothalamo–pituitary–testicular (HPT) axis, mutations in only 75 genes have so far been shown to cause delayed puberty. Methods Six male patients… read more here.
Keywords: hpt axis; puberty; whole exome; group ... See more keywords
Genetic Regulation in Pubertal Delay.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular endocrinology"
DOI: 10.1530/jme-19-0130
Abstract: Delayed puberty represents the clinical presentation of a final common pathway for many different pathological mechanisms. In the majority of patients presenting with significantly delayed puberty there is a clear family history of delayed or… read more here.
Keywords: regulation pubertal; puberty; pubertal delay; genetic regulation ... See more keywords