Cancer immunotherapy trial design with cure rate and delayed treatment effect.
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DOI: 10.1002/sim.8440
Abstract: Cancer immunotherapy trials have two special features: a delayed treatment effect and a cure rate. Both features violate the proportional hazard model assumption and ignoring either one of the two features in an immunotherapy trial… read more here.
Keywords: delayed treatment; cure rate; trial; design ... See more keywords
The consequences of delayed treatment in doxorubicin extravasation
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Plastic Surgery"
DOI: 10.1007/s00238-020-01715-y
Abstract: Doxorubicin (Adriamycin) is an anthracycline chemotherapy agent used for the treatment of several cancers including haematological malignancies. Extravasation is a well-recognized and possibly serious complication of administered intravenous therapies, especially in chemotherapeutic agents. Drug extravasation… read more here.
Keywords: doxorubicin extravasation; treatment; treatment doxorubicin; tissue ... See more keywords
Glycyrrhizin Prevents Hemorrhagic Transformation and Improves Neurological Outcome in Ischemic Stroke with Delayed Thrombolysis Through Targeting Peroxynitrite-Mediated HMGB1 Signaling
Sign Up to like & getrecommendations! Published in 2019 at "Translational Stroke Research"
DOI: 10.1007/s12975-019-00772-1
Abstract: Peroxynitrite (ONOO−) and high mobility group box 1 protein (HMGB1) are important cytotoxic factors contributing to cerebral ischemia-reperfusion injury. However, the roles of ONOO− in mediating HMGB1 expression and its impacts on hemorrhagic transformation (HT)… read more here.
Keywords: hmgb1; hemorrhagic transformation; ischemic stroke; delayed treatment ... See more keywords
O37 Salidroside prevents toxicity induced by delayed treatment of tPA in a rat model of focal cerebral ischemia involving PKA-and PI3K-dependent Akt activation
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DOI: 10.1016/j.bcp.2017.06.102
Abstract: Ischemic stroke is currently treated with thrombolytic therapy with the drawback that it induces hemorrhagic transformation (HT) if applied beyond its relatively narrow treatment time window. The present study was designed to examine the role… read more here.
Keywords: treatment; delayed treatment; toxicity; pi3k dependent ... See more keywords
Reasons for delayed treatment initiation in Guillain-Barre syndrome
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the Neurological Sciences"
DOI: 10.1016/j.jns.2022.120179
Abstract: OBJECTIVE The goal of this study was to analyze the reasons for delayed diagnosis of Guillain-Barre syndrome (GBS). METHODS We retrospectively reviewed the records of all adult patients with GBS treated at Shamir Medical Center… read more here.
Keywords: guillain barre; barre syndrome; delayed treatment; initiation ... See more keywords
A delayed treatment model for the evaluation of scopolamine for VX nerve agent intoxication.
Sign Up to like & getrecommendations! Published in 2021 at "Toxicology and applied pharmacology"
DOI: 10.1016/j.taap.2021.115650
Abstract: Most research on medical countermeasures for nerve agent exposure assumes a military scenario, in which (autoinjector) treatment is envisaged to be immediately available. In a civilian setting however, treatment is delayed until arrival of first-aid… read more here.
Keywords: scopolamine; treatment; exposure; delayed treatment ... See more keywords
High Dose and Delayed Treatment with Bile Acids Ineffective in RML Prion-Infected Mice
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DOI: 10.1128/aac.00222-18
Abstract: ABSTRACT Prion diseases are a group of neurodegenerative diseases associated with the misfolding of the cellular prion protein (PrPC) into the infectious form (PrPSc). There are currently no treatments for prion disease. Bile acids have… read more here.
Keywords: bile acids; high dose; treatment; prion ... See more keywords
Abstract TP74: Delayed Treatment of Intravenous Thrombolysis in Stroke Patients With Minor Stroke
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DOI: 10.1161/str.49.suppl_1.tp74
Abstract: Background and purpose: Rapid administration of IV tissue plasminogen activator (tPA) is crucial for better outcome in acute stroke treatment. While IV tPA is more frequently used in patients with ... read more here.
Keywords: tp74 delayed; treatment; delayed treatment; abstract tp74 ... See more keywords
A group sequential design and sample size estimation for an immunotherapy trial with a delayed treatment effect
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DOI: 10.1177/0962280220980780
Abstract: A delayed treatment effect is often observed in the confirmatory trials for immunotherapies and is reflected by a delayed separation of the survival curves of the immunotherapy groups versus the control groups. This phenomenon makes… read more here.
Keywords: design; group sequential; delayed treatment; sample size ... See more keywords
Is qSOFA Suitable for Early Diagnosis of Sepsis Among Bacteremia Patients in Emergency Departments? Time for a Reappraisal of Sepsis-3 Criteria
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DOI: 10.3389/fmed.2021.743822
Abstract: Background: For early recognition of patients with sepsis, quick Sequential Organ Failure Assessment (qSOFA) was proposed by Sepsis-3 criteria as initial sepsis identification outside of intensive care units. However, the new definition has subsequently led… read more here.
Keywords: sepsis; treatment efforts; sepsis criteria; delayed treatment ... See more keywords
Systemic Immune Modulation Alters Local Bone Regeneration in a Delayed Treatment Composite Model of Non-Union Extremity Trauma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Surgery"
DOI: 10.3389/fsurg.2022.934773
Abstract: Bone non-unions resulting from severe traumatic injuries pose significant clinical challenges, and the biological factors that drive progression towards and healing from these injuries are still not well understood. Recently, a dysregulated systemic immune response… read more here.
Keywords: treatment; delayed treatment; bone regeneration; systemic immune ... See more keywords