Resolving Deleterious and Near-Neutral Effects Requires Different Pooled Fitness Assay Designs
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Molecular Evolution"
DOI: 10.1101/2022.08.19.504558
Abstract: Pooled sequencing-based fitness assays are a powerful and widely used approach to quantifying fitness of thousands of genetic variants in parallel. Despite the throughput of such assays, they are prone to biases in fitness estimates,… read more here.
Keywords: pooled fitness; neutral effects; fitness effects; deleterious near ... See more keywords