Genetic Deletion of KLHL1 Leads to Hyperexcitability in Hypothalamic POMC Neurons and Lack of Electrical Responses to Leptin
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DOI: 10.3389/fnins.2021.718464
Abstract: Kelch-like 1 (KLHL1) is a neuronal actin-binding protein that modulates voltage-gated calcium channels. The KLHL1 knockout (KO) model displays altered calcium channel expression in various brain regions. We analyzed the electrical behavior of hypothalamic POMC… read more here.
Keywords: pomc neurons; type channels; deletion klhl1; hypothalamic pomc ... See more keywords