Conditional deletion of KOR (Oprk1) in kisspeptin cells does not alter LH pulses, puberty, or fertility in mice.
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DOI: 10.1210/endocr/bqac175
Abstract: Classic pharmacological studies suggested that endogenous dynorphin-KOR signaling is important for reproductive neuroendocrine regulation. With the seminal discovery of an interconnected network of hypothalamic arcuate neurons co-expressing kisspeptin, neurokinin B, and dynorphin ("KNDy neurons"), the… read more here.
Keywords: kisspeptin cells; hypothesis; kisspeptin; kndy neurons ... See more keywords