Heterotrimeric PCNA increases the activity and fidelity of Dbh, a Y-family translesion DNA polymerase prone to creating single-base deletion mutations.
Sign Up to like & getrecommendations! Published in 2020 at "DNA repair"
DOI: 10.1016/j.dnarep.2020.102967
Abstract: Dbh is a Y-family translesion DNA polymerase from Sulfolobus acidocaldarius, an archaeal species that grows in harsh environmental conditions. Biochemically, Dbh displays a distinctive mutational profile, creating single-base deletion mutations at extraordinarily high frequencies (up… read more here.
Keywords: base deletion; deletion mutations; single base; dna ... See more keywords
Correcting “insertion‐deletion mutations” in medical terminology
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.13875
Abstract: The human genome and written language share analogous substructures: linear strings of letters forming functional‐structural molecular units resemble alphabetical letters which, arranged in a linear fashion, form words; these strings become more than the sum… read more here.
Keywords: medicine; terminology; insertion deletion; disease ... See more keywords
Insertion-and-Deletion Mutations between the Genomes of SARS-CoV, SARS-CoV-2, and Bat Coronavirus RaTG13
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.00716-22
Abstract: The developmental mechanism of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains inconclusive. This study compared the base sequence one-by-one between severe acute respiratory syndrome coronavirus (SARS-CoV) or bat coronavirus RaTG13 and SARS-CoV-2. ABSTRACT The… read more here.
Keywords: insertion deletion; coronavirus; deletion mutations; sars cov ... See more keywords