Glutathione S-Transferase Gene Polymorphisms as Predictors of Methotrexate Efficacy in Juvenile Idiopathic Arthritis
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DOI: 10.3390/biomedicines12081642
Abstract: Because of the unpredictable efficacy of methotrexate (MTX) in the treatment of juvenile idiopathic arthritis (JIA), the possibility of a favourable outcome is reduced in more than 30% of patients. To investigate the possible influence… read more here.
Keywords: glutathione transferase; deletion polymorphisms; juvenile idiopathic; efficacy ... See more keywords
Balancing selection on genomic deletion polymorphisms in humans
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DOI: 10.7554/elife.79111
Abstract: A key question in biology is why genomic variation persists in a population for extended periods. Recent studies have identified examples of genomic deletions that have remained polymorphic in the human lineage for hundreds of… read more here.
Keywords: deletion polymorphisms; selection genomic; balancing selection; polymorphisms humans ... See more keywords