Engineering large-scale chromosomal deletions by CRISPR-Cas9.
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DOI: 10.1093/nar/gkab557
Abstract: Large-scale chromosomal deletions are a prevalent and defining feature of cancer. A high degree of tumor-type and subtype specific recurrencies suggest a selective oncogenic advantage. However, due to their large size it has been difficult… read more here.
Keywords: large scale; scale chromosomal; deletions crispr; chromosomal deletions ... See more keywords