Rapid detection of the New Delhi metallo‐b‐lactamase 1 (NDM‐1) gene by loop‐mediated isothermal amplification (LAMP)
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.22323
Abstract: New Delhi Metallo‐b‐lactamase (NDM‐1) is an enzyme emerging around the world conferring resistance to a wide range of β‐lactams agents and whose early detection is extremely important. We proposed to standardize the detection of the… read more here.
Keywords: loop mediated; detection; new delhi; lactamase ndm ... See more keywords
NMR backbone resonance assignment of New Delhi metallo-beta-lactamase
Sign Up to like & getrecommendations! Published in 2017 at "Biomolecular NMR Assignments"
DOI: 10.1007/s12104-017-9756-5
Abstract: The emerging of the New Delhi metallo-beta-lactamase (NDM-1) has become one of the greatest threats to the clinical treatment. Although the structure of NDM-1 has been determined by X-ray crystallography, the molecular mechanism and process… read more here.
Keywords: new delhi; beta lactamase; metallo beta; spectroscopy ... See more keywords
Bioisosteric investigation of ebselen: Synthesis and in vitro characterization of 1,2-benzisothiazol-3(2H)-one derivatives as potent New Delhi metallo-β-lactamase inhibitors.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.103873
Abstract: Carbapenem-resistant Enterobacteriaceae (CRE) producing New Delhi metallo-β-lactamase (NDM-1) cause untreatable bacterial infections, posing a significant threat to human health. In the present study, by employing the concept of bioisosteric replacement of the selenium moiety of… read more here.
Keywords: new delhi; benzisothiazol one; one derivatives; metallo lactamase ... See more keywords
Stereochemically altered cephalosporins as potent inhibitors of New Delhi metallo-β-lactamases.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2022.114174
Abstract: Antibiotic resistance caused by β-lactamases, particularly metallo-β-lactamases, has been a major threat to public health globally. New Delhi metallo-β-lactamase-1 (NDM-1) represents one of the most important metallo-β-lactamases; the production of NDM-1 in bacterial pathogen significantly… read more here.
Keywords: new delhi; metallo lactamases; metallo; stereochemically altered ... See more keywords
Frequency Distribution, Genotypes and the most Prevalent Sequence Types of New Delhi Metallo-beta-lactamase-Producing Escherichia coli among Clinical Isolates around the World; A Review.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of global antimicrobial resistance"
DOI: 10.1016/j.jgar.2019.06.008
Abstract: BACKGROUND AND AIM New Delhi Metallo-beta-lactamase (NDM)-producing Escherichia coli (E. coli) is allegedly perceived as one of the primary multidrug-resistant bacteria causing infections in hospitals and clinics. In this paper we present the frequency distribution,… read more here.
Keywords: new delhi; beta lactamase; coli; metallo beta ... See more keywords
Identification and control of two outbreaks of unrelated New Delhi metallo-β-lactamase-producing carbapenem-resistant Escherichia coli traced to the same endoscope defect.
Sign Up to like & getrecommendations! Published in 2023 at "Infection control and hospital epidemiology"
DOI: 10.1017/ice.2023.21
Abstract: We report 2 outbreaks of genetically unrelated carbapenem-resistant New Delhi metallo-β-lactamase-producing Escherichia coli caused by contaminated duodenoscopes. Using endoscopes with disposable end caps, adherence to the manufacturer's reprocessing instructions, routine audits, and manufacturer evaluation are… read more here.
Keywords: carbapenem resistant; escherichia coli; new delhi; metallo lactamase ... See more keywords
Novel Mercapto Propionamide Derivatives with Potent New Delhi Metallo-β-Lactamase-1 Inhibitory Activity and Low Toxicity.
Sign Up to like & getrecommendations! Published in 2019 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.8b00366
Abstract: The emergence and worldwide prevalence of New Delhi metallo-β-lactamase 1 (NDM-1) expressing Gram-negative bacteria with resistance against most β-lactam antibiotics pose a serious threat to human health. However, no NDM-1 inhibitors are clinically approved at… read more here.
Keywords: toxicity; new delhi; metallo lactamase; delhi metallo ... See more keywords
Computationally designed peptide macrocycle inhibitors of New Delhi metallo-β-lactamase 1
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2012800118
Abstract: Significance Peptide macrocycles are a promising class of drugs, but their weakness is conformational flexibility: target affinity can be limited by an unfavorable transition from a disordered unbound state to an ordered bound state. We… read more here.
Keywords: new delhi; inhibitors new; metallo lactamase; delhi metallo ... See more keywords
Abundance of New Delhi Metallo-β-Lactamase-Producing Acinetobacter, Escherichia, Proteus, and Pseudomonas spp. in Mahananda and Karala Rivers of India.
Sign Up to like & getrecommendations! Published in 2021 at "Microbial drug resistance"
DOI: 10.1089/mdr.2019.0449
Abstract: In this study, we report a high incidence of New Delhi metallo-β-lactamase (NDM)-producing and ampicillin-catabolizing bacteria within carbapenem-resistant bacterial populations in the waters of two important rivers, Mahananda and Karala, bisecting two most populous towns,… read more here.
Keywords: new delhi; acinetobacter escherichia; escherichia proteus; mahananda karala ... See more keywords
Cystatins 9 and C as a Novel Immunotherapy Treatment That Protects against Multidrug-Resistant New Delhi Metallo-Beta-Lactamase-1-Producing Klebsiella pneumoniae
Sign Up to like & getrecommendations! Published in 2017 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.01900-17
Abstract: ABSTRACT Multidrug-resistant (MDR) bacterial pneumonia can induce dysregulated pulmonary and systemic inflammation leading to morbidity and mortality. Antibiotics to treat MDR pathogens do not function to modulate the extent and intensity of inflammation and can… read more here.
Keywords: new delhi; treatment; pneumoniae; infected mice ... See more keywords
Emergence of Hybrid Resistance and Virulence Plasmids Harboring New Delhi Metallo-β-Lactamase in Klebsiella pneumoniae in Russia
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DOI: 10.3390/antibiotics10060691
Abstract: The emergence of carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKp) is a new threat to healthcare. In this study, we analyzed nine CR-hvKp isolates of different sequence-types (ST) recovered from patients with nosocomial infections in two hospitals… read more here.
Keywords: new delhi; hybrid plasmids; resistance; klebsiella pneumoniae ... See more keywords