Involvement of acute neuroinflammation in postoperative delirium-like cognitive deficits in rats
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Anesthesia"
DOI: 10.1007/s00540-018-2504-x
Abstract: PurposeThe purpose of this study was to investigate the age-, time-, and brain region-dependent postoperative neuroinflammatory trajectory, and its association with neurocognitive outcomes in rats.MethodsAdult and aged rats were randomly assigned to one of three… read more here.
Keywords: delirium like; acute neuroinflammation; like cognitive; neuroinflammation ... See more keywords
Orthopedic Surgery Triggers Attention Deficits in a Delirium-Like Mouse Model
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.02675
Abstract: Postoperative delirium is a frequent and debilitating complication, especially amongst high risk procedures such as orthopedic surgery, and its pathogenesis remains unclear. Inattention is often reported in the clinical diagnosis of delirium, however limited attempts… read more here.
Keywords: orthopedic surgery; delirium like; surgery; attention ... See more keywords
Reactive oxygen species contribute to delirium-like behavior by activating CypA/MMP9 signaling and inducing blood-brain barrier impairment in aged mice following anesthesia and surgery
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.1021129
Abstract: Postoperative delirium (POD) is common in the elderly and is associated with poor clinical outcomes. Reactive oxygen species (ROS) and blood-brain barrier (BBB) damage have been implicated in the development of POD, but the association… read more here.
Keywords: anesthesia surgery; delirium like; anesthesia; cypa mmp9 ... See more keywords