Development of a Modular Ribonucleoprotein Complex as a General Strategy to Deliver RNAi Therapeutics
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202503281
Abstract: RNAi therapeutics can potentially address undruggable diseases. However, their full potential is stymied by delivery challenges. An siRNA delivery platform by remodeling the human U4 small nuclear ribonucleoprotein complex (snRNP) is developed. This remodeled protein‐siRNA… read more here.
Keywords: deliver; delivery; ribonucleoprotein complex; rnai therapeutics ... See more keywords
Evaluation of the efficiency of modified PAMAM dendrimer with low molecular weight protamine peptide to deliver IL‐12 plasmid into stem cells as cancer therapy vehicles
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology Progress"
DOI: 10.1002/btpr.3175
Abstract: Interleukin 12 (IL‐12) is considered as an important molecule for cancer immunotherapy with significant roles in hindering tumor activity, mostly mediated by tumor‐associated macrophages and anti‐angiogenic factors. Mesenchymal stem cells (MSCs) have been come out… read more here.
Keywords: deliver; modified pamam; cancer; efficiency ... See more keywords
Optimizing restoration: A holistic spatial approach to deliver Nature’s Contributions to People with minimal tradeoffs and maximal equity
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2402970121
Abstract: Significance Delivery of ecosystem restoration plans can lead to gains and losses of environmental and societal benefits, disproportionately impacting different groups of society. The tradeoffs and inequity can potentially be large when considering plans focused… read more here.
Keywords: deliver; restoration; minimal tradeoffs; restoration holistic ... See more keywords
Can They Deliver?
Sign Up to like & getrecommendations! Published in 2024 at "Journal of International Criminal Justice"
DOI: 10.1093/jicj/mqae005
Abstract: Joint Investigation Teams or JITs are practical mechanisms of cooperation that are established between two or more states to, jointly, conduct criminal investigations. Increasingly used in investigations into core international crimes (war crimes, genocide, crimes… read more here.
Keywords: deliver;
Where Will You Deliver this Fetus with an Abnormal Echocardiogram?
Sign Up to like & getrecommendations! Published in 2020 at "NeoReviews"
DOI: 10.1542/neo.21-12-e847
Abstract: You are a neonatologist in a small rural hospital with a newborn nursery and no pediatric cardiology services. The nearest hospital with a NICU and pediatric cardiology services is 50 miles away. The closest tertiary… read more here.
Keywords: echocardiogram; cardiology; deliver; hospital ... See more keywords