Restoration of Sinusoid Fenestrae Followed by Targeted Nanoassembly Delivery of an Anti‐Fibrotic Agent Improves Treatment Efficacy in Liver Fibrosis
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Materials"
DOI: 10.1002/adma.202212206
Abstract: During the onset of liver fibrosis, capillarized liver sinusoidal endothelial cells (LSECs) limit substance exchange between the blood and the Disse space, further accelerating hepatic stellate cell (HSCs) activation and fibrosis progression. Limited accessibility of… read more here.
Keywords: liver fibrosis; delivery anti; ignp jq1; treatment ... See more keywords
Highly antibacterial polypeptide-based amphiphilic copolymers as multifunctional non-viral vectors for enhanced intracellular siRNA delivery and anti-infection.
Sign Up to like & getrecommendations! Published in 2017 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2017.06.010
Abstract: For next-generation regenerative medicine and cancer therapy applications, the development of multifunctional biodegradable biomaterials with good antibacterial activity, biocompatibility and gene delivery capability is showing increased interests. As a natural cationic polypeptide, poly(ε-l-lysine) (EPL) has… read more here.
Keywords: delivery anti; sirna delivery; gene; sirna ... See more keywords
Intracellular Delivery of Anti-Kirsten Rat Sarcoma Antibodies Mediated by Polymeric Micelles Exerts Strong In Vitro and In Vivo Anti-Tumorigenic Activity in Kirsten Rat Sarcoma-Mutated Cancers.
Sign Up to like & getrecommendations! Published in 2023 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c19897
Abstract: The Kirsten rat sarcoma viral oncogene (KRAS) is one of the most well-known proto-oncogenes, frequently mutated in pancreatic and colorectal cancers, among others. We hypothesized that the intracellular delivery of anti-KRAS antibodies (KRAS-Ab) with biodegradable… read more here.
Keywords: kirsten rat; intracellular delivery; delivery anti; rat sarcoma ... See more keywords
Assisted delivery of anti-tumour platinum drugs using DNA-coiling gold nanoparticles bearing lumophores and intercalators: towards a new generation of multimodal nanocarriers with enhanced action
Sign Up to like & getrecommendations! Published in 2019 at "Chemical Science"
DOI: 10.1039/c9sc02640a
Abstract: Nanocarriers with unusual DNA binding properties provide enhanced cytotoxic activity beyond that conferred by the platinum agents they release. read more here.
Keywords: dna; anti tumour; assisted delivery; platinum ... See more keywords
Targeted delivery of an anti-inflammatory corticosteroid to Ly6C/G-positive cells abates severity of influenza A symptoms
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2211065119
Abstract: Significance Viruses that target the respiratory tract can inflict pulmonary damage, with acute respiratory distress syndrome (ARDS) as a potentially fatal outcome. Neutrophils are key actors in ARDS. Here, we use nanobodies that target Ly6C/G,… read more here.
Keywords: delivery anti; inflammatory corticosteroid; influenza; anti inflammatory ... See more keywords
Synthetic DNA-Encoded Monoclonal Antibody Delivery of Anti-CTLA-4 Antibodies Induces Tumor Shrinkage In Vivo.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer research"
DOI: 10.1158/0008-5472.can-18-1429
Abstract: Antibody-based immune therapies targeting the T-cell checkpoint molecules CTLA-4 and PD-1 have affected cancer therapy. However, this immune therapy requires complex manufacturing and frequent dosing, limiting the global use of this treatment. Here, we focused… read more here.
Keywords: delivery anti; ctla; delivery; antibody ... See more keywords
Harmonious biomaterials for development of in situ approaches for locoregional delivery of anti-cancer drugs: current trends.
Sign Up to like & getrecommendations! Published in 2019 at "Current medicinal chemistry"
DOI: 10.2174/1573406415666190621095726
Abstract: Locoregional drug delivery is a novel approach for the effective delivery of anti-cancer agents as it exposes the tumors to high concentration of drugs. In situ gelling systems have fetched paramount attention in the field… read more here.
Keywords: delivery anti; delivery; drug; situ ... See more keywords
Novel Approaches for the Delivery of Anti-HIV Drugs-What Is New?
Sign Up to like & getrecommendations! Published in 2019 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics11110554
Abstract: HIV/AIDS continues to be one of the most challenging individual and public health concerns of our days [...] read more here.
Keywords: anti hiv; novel approaches; hiv drugs; hiv ... See more keywords