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Published in 2017 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2017.04.068
Abstract: The present article demonstrates the targeted delivery of doxorubicin hydrochloride to human osteosarcoma cancer cell lines (MG 63) using functionalized dextrin based crosslinked, pH responsive and biocompatible nanogel. The nanogel has been prepared through Michael-type… read more here.
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Published in 2020 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2019.115745
Abstract: Hydrogels are promising carriers for the controlled drug delivery in response to the external stimuli such as pH and temperature. Here, a new hydrogel is designed and synthesized from the cross-linking of graphene, chitosan, and… read more here.
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Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.12.215
Abstract: The aim of this work was to examine the formation and properties of a novel polyelectrolyte complex of drug carrier system for the delivery of doxorubicin (DOX), which consists of hyaluronic acid (HA) coated hydrophobically… read more here.
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Published in 2018 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.8b00342
Abstract: Mammalian telomerase maintains the length and integrity of telomeres by adding the telomeric repeats to the chromosome end. This work describes the telomerase responsive delivery of doxorubicin against telomerase positive human and murine cancer cells.… read more here.
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Published in 2019 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.8b00862
Abstract: A combination of different chemotherapy approaches can obtain the best response for many cancers. However, the greatest challenge is the development of a nanoparticle formulation that can encapsulate different chemotherapeutic agents to achieve the proper… read more here.
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Published in 2020 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2020.1794968
Abstract: Abstract Dual delivery of Doxorubicin (DOX) and Paclitaxel (PTX) anticancer drug molecules with boron nitride (BN) and phosphorene (PH) nanosheets are investigated using molecular dynamics (MD) simulation. Several quantities are employed to examine the adsorption… read more here.
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Published in 2020 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaa222.047
Abstract: Abstract DIPGs are the most aggressive pediatric brain tumors. Currently, the only treatment is irradiation but due to its palliative nature patients die within 12 months. Effective delivery of chemotherapy across the blood-brain barrier (BBB)… read more here.
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Published in 2017 at "Nanomedicine"
DOI: 10.2217/nnm-2017-0243
Abstract: AIM Facile development of polysaccharides-based carrier system for efficient delivery of doxorubicin (DOX) to the brain. METHODS DOX was nanocomplexed with alginate (Alg) followed by incorporation into chitosan (Cs) nanomatrices. The resulting carriers were optimized… read more here.
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Published in 2018 at "Nanomedicine"
DOI: 10.2217/nnm-2017-0375
Abstract: AIM To build up a combined therapy strategy to address limitations of the enhanced permeability and retention (EPR) effect and improve the efficiency of tumor therapy. MATERIALS & METHODS A pH-sensitive nanocomplex for co-delivery of… read more here.