Microneedle and Iontophoresis Mediated Delivery of Methotrexate into and across Healthy and Psoriatic Skin.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2022.121693
Abstract: Psoriasis is a condition of the skin which involves scales, dry patches, and inflammation. Methotrexate (logP: -1.8, MW:454.44g/mol) is administered orally or intravenously to treat psoriasis. The first-pass metabolism and systemic toxicity can be avoided… read more here.
Keywords: delivery; healthy psoriatic; delivery methotrexate; psoriatic skin ... See more keywords
Targeted delivery of methotrexate using a new PEGylated magnetic/gold nanoplatform covered with pH‐responsive shell
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Polymeric Materials and Polymeric Biomaterials"
DOI: 10.1080/00914037.2020.1740994
Abstract: Abstract Because of nonspecific biodistribution, and the resistance of cancer cells to chemotherapeutic agents, it is possible to develop cancer nanotherapeutics that are being replaced to solve these limitations. So, the fabrication of smart nano‐sized… read more here.
Keywords: delivery methotrexate; delivery; magnetic gold; targeted delivery ... See more keywords
Polymeric Nanoscale Drug Carriers Mediate the Delivery of Methotrexate for Developing Therapeutic Interventions Against Cancer and Rheumatoid Arthritis
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.01734
Abstract: Methotrexate (MTX) is widely used as an anticancer and anti-inflammtory drug for treating various types of cancer and autoimmune diseases. The optimal dose of MTX is known to inhibit the dihydrofolatereductase that hinders the replication… read more here.
Keywords: polymeric nanoscale; methotrexate; delivery; drug ... See more keywords